Sex difference in acute renal dysfunction induced by methylmercury in mice

Renal Failure
A YasutakeM Inouye

Abstract

To investigate the sex-related difference of susceptibility of renal function to methylmercury (MeHg) toxicity, various doses of MeHg chloride (MMC, 20-200 mumol/kg) were orally administered to C57BL/6N mice of both sexes. On days 1, 3, 5, and 7 after MMC administration, the extent of damage to renal function and the renal Hg levels were examined. After dosing, female mice survived much longer than males. With the increase in the dose level to 200 mumol/kg, the changes of the renal Hg levels 24 h after administration showed biphasic features with a plateau of around 85 micrograms/g. The renal Hg in male mice increased more rapidly to the plateau than in females. The doses by which the renal Hg level reached the plateau were 80 and 120 mumol/kg for males and females, respectively. The time-dependent decrease of the renal Hg became much slower with dose levels exceeding 80 and 160 mumol/kg for males and females, respectively. Inhibition of phenolsulfonphthalein excretion and increase of plasma creatinine after the MMC administration were more marked in males than in females. Inorganic Hg levels in the kidney of MeHg-intoxicated mice were much lower than that of HgCl2-intoxicated mice, indicating that the involvement of inorganic ...Continue Reading

References

Nov 1, 1990·Bulletin of Environmental Contamination and Toxicology·A Yasutake, K Hirayama
Jan 1, 1989·Archives of Toxicology·A YasutakeM Inoue
Jan 1, 1986·Journal of Toxicology and Environmental Health·K Hirayama, A Yasutake
Apr 1, 1973·Toxicology and Applied Pharmacology·F IversonH L Trenholm
Dec 1, 1970·Archives of Environmental Health·T Norseth, T W Clarkson
Aug 1, 1984·Nihon juigaku zasshi. The Japanese journal of veterinary science·K MitsumoriY Shirasu
Dec 1, 1983·Nihon juigaku zasshi. The Japanese journal of veterinary science·K MitsumoriY Shirasu
Jul 1, 1981·Acta Pharmacologica Et Toxicologica·M Mehra, B H Choi
Dec 1, 1960·American Industrial Hygiene Association Journal·M B JACOBSH GILBERT

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Citations

Jan 1, 1994·Archives of Toxicology·A Yasutake, K Hirayama
Apr 1, 1993·Environmental Health Perspectives·B A Fowler
Sep 30, 2008·Journal of Applied Toxicology : JAT·Xiaolei JinRekha Mehta
Oct 12, 2010·The Journal of Toxicological Sciences·Akira YasutakeMinoru Yoshida
Jul 1, 1997·The Tohoku Journal of Experimental Medicine·A YasutakeK Eto
Jan 25, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Moumita Pal, M Ghosh
Mar 13, 2009·Critical Reviews in Toxicology·Shirlee W TanKathryn R Mahaffey

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