PMID: 9442352Jan 27, 1998Paper

Sex difference in glucocorticoid regulation of vasopressin mRNA in the paraventricular hypothalamic nucleus

Cellular and Molecular Neurobiology
M FerriniA F De Nicola

Abstract

1. Arginine vasopressin (AVP) is synthesized in specific brain regions including the magnocellular and parvocellular divisions of the paraventricular nucleus (PVN). Whereas magnocellular AVP responds to osmotic stimuli and functions mainly--although not exclusively--as an antidiuretic hormone, that produced in the parvocellular region controls the hypothalamus-pituitary-adrenal (HPA) axis, in conjunction with CRF. 2. In view of the reported sex differences in control of the HPA axis, we studied if these also pertain to AVP mRNA in the PVN of ovariectomized-estrogenized female rats and male rats determined by in situ hybridization. AVP mRNA was measured in intact rats, adrenalectomized (ADX) rats and ADX receiving dexamethasone (DEX) of both sexes. 3. Computerized autoradiography showed that in both sexes, AVP mRNA levels in the parvocellular division of the PVN increased after adrenalectomy and decreased following DEX. However, the reduction by DEX was more pronounced in female rats. No changes were found for the magnocellular region. Grain counting analysis of the medial-medial (MMP) and medial-lateral (MLP) subdivisions of the parvocellular region showed that the average number of grains per cell area in the MMP region of adr...Continue Reading

Citations

Mar 28, 2008·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Lieve DesbonnetTimothy G Dinan
Apr 23, 2009·Alcoholism, Clinical and Experimental Research·Ni LanJoanne Weinberg
Feb 7, 2018·Journal of Psychopharmacology·Blanca Bolea-AlamanacRita Valentino
Aug 17, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ashley L Heck, Robert J Handa
Aug 12, 1998·The Journal of Steroid Biochemistry and Molecular Biology·A F De NicolaE R de Kloet
Sep 25, 2021·Journal of Neurovirology·Asante R KamkwalalaLeah H Rubin

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