PMID: 2116494Jul 1, 1990Paper

Sex difference in growth hormone feedback in the rat

The Journal of Endocrinology
L M CarlssonI C Robinson

Abstract

Growth hormone inhibits its own secretion in animals and man but the mechanism for this inhibition is unclear: both stimulation of somatostatin release and inhibition of GH-releasing factor (GRF) release have been implicated. We have now studied the GRF responsiveness of conscious male and female rats under conditions of GH feedback induced by constant infusion of exogenous human GH (hGH). Intravenous infusions of hGH (60 micrograms/h) were maintained for 3 to 6 h whilst serial injections of GRF(1-29)NH2 (0.2-1 microgram) were given at 45-min intervals. The GH responses were studied by assaying blood samples withdrawn at frequent intervals using an automatic blood sampling system. We have confirmed that male and female rats differ in their ability to respond to a series of GRF injections; female rats produced consistent GH responses for up to 13 consecutive GRF injections, whereas male rats showed a 3-hourly pattern of intermittent responsiveness. In female rats, multiple injections of GRF continued to elicit uniform GH responses during hGH infusions, whereas hGH infusions in male rats disturbed their intermittent pattern of responsiveness to GRF, and their regular 3-hourly cycle of refractoriness was prolonged. We suggest that...Continue Reading

Citations

Jan 1, 1991·Pharmacology & Therapeutics·M H Hastings
Jun 28, 2003·Neurobiology of Aging·Johannes D Veldhuis
Apr 7, 2011·American Journal of Physiology. Endocrinology and Metabolism·Johannes D VeldhuisCyril Y Bowers
Jul 29, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Johannes D Veldhuis, Cyril Y Bowers
Jul 3, 1998·The Journal of Clinical Investigation·C A JaffeA L Barkan
Feb 25, 2005·The Journal of Clinical Endocrinology and Metabolism·Johannes D VeldhuisLaurie Wideman
Sep 16, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·J D Veldhuis
May 3, 2015·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Hui Ying LukWesley C Hymer
Feb 19, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Leon S Farhy, Johannes D Veldhuis
Sep 1, 1993·Molecular Reproduction and Development·K MatsumotoA Iritani
Jan 1, 1991·Acta Paediatrica Scandinavica. Supplement·I C Robinson
Nov 11, 2005·Journal of Neuroendocrinology·D J MacGregor, G Leng
Dec 23, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Leon S FarhyJohannes D Veldhuis
Dec 12, 2001·The Journal of Clinical Endocrinology and Metabolism·S M AndersonJ D Veldhuis
Sep 27, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·L WidemanJ D Veldhuis
Jun 19, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·L S FarhyJ D Veldhuis
Apr 30, 1999·Physiological Reviews·E E MüllerD Cocchi
Feb 8, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Leon S FarhyJohannes D Veldhuis
Mar 5, 1998·The American Journal of Physiology·E GeversJ D Veldhuis
Dec 9, 1998·The American Journal of Physiology·C WagnerG S Tannenbaum

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.