Sex difference in immune response to vaccination: A participant-level meta-analysis of randomized trials of IMVAMUNE smallpox vaccine

Vaccine
Jesse D TroySharon E Frey

Abstract

Previous research shows immune response to vaccination differs by sex but this has not been explored for IMVAMUNE, a replication-deficient smallpox vaccine developed in response to the potential for bioterrorism using smallpox. We conducted a participant-level meta-analysis (N=275, 136 men, 139 women) of 3 randomized trials of IMVAMUNE conducted at 13 centers in the US through a federally-funded extramural research program. Studies were eligible for inclusion if they tested the standard dose (1×10(8)TCID₅₀/mL on Days 0 and 28) of liquid formulation IMVAMUNE, were completed at the time of our search, and enrolled healthy vaccinia-naïve participants. Models of the peak log₂ ELISA and PRNT titers post-second vaccination were constructed for each study with sex as a covariate. Results from these models were combined into random effects meta-analyses of the sex difference in response to IMVAMUNE. We then compared this approach with fixed effects models using the combined participant level data. In each study the mean peak log₂ ELISA titer was higher in men than women but no single study demonstrated a statistically significant difference. Combination of the adjusted study-specific estimates into the random effects model showed a hig...Continue Reading

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Citations

Dec 15, 2016·Human Vaccines & Immunotherapeutics·Marc DemeulemeesterStéphane Heijmans
Sep 25, 2017·Human Vaccines & Immunotherapeutics·Mathilde Latreille-BarbierYves Donazzolo
Aug 2, 2019·Military Medicine·Mohana Priya KunasekaranChandini Raina MacIntyre
Oct 11, 2017·Annual Review of Cell and Developmental Biology·Katie L FlanaganSabra L Klein
May 24, 2020·Viruses·Valentina CostantinoRaina MacIntyre
Oct 20, 2020·Current Opinion in Physiology·Katherine S Forsyth, Montserrat C Anguera

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