PMID: 708787Oct 18, 1978Paper

Sex difference in L-glutamine D-fructose-6-phosphate aminotransferase activity of mouse submandibular gland

Biochimica Et Biophysica Acta
K HosoiT Ueha


L-Glutamine D-fructose-6-phosphate aminotransferase (2-amino-2-deoxy-D-glucose-6-phosphate ketol-isomerase (amino-transferring), EC activities in the three main salivary glands of male and female mice were measured. It was found that the activity in the submandibular gland was about 10 times more in females than in males, whereas the activities in the sublingual and parotid glands of males and females were similar. The activity in the submandibular gland of female mice was not affected appreciably by ovariectomy but it decreased to the level in males on injection of testosterone. The activity in males was not affected appreciably by injection of progesterone or 17beta-estradiol, but it increased to the level in females after castration. The increased activity in castrated male mice was decreased again to the normal level by testosterone injection. Thus, this sex difference is caused by androgen, not by female hormones. On the basis of in vivo experiments using actinomycin D, it was suggested that testosterone produced an "enzyme inhibitor", which suppressed the enzyme activity in the submandibular glands of androgen-rich animals.


Nov 27, 1962·Biochemical and Biophysical Research Communications·A M GOTTO, B M POGELL
Aug 1, 1964·Proceedings of the National Academy of Sciences of the United States of America·S KORNFELDP J O'BRIEN
Sep 15, 1962·Proceedings of the National Academy of Sciences of the United States of America·C LEVINTHALA HIGA


Mar 6, 2007·Seminars in Cell & Developmental Biology·A S Tucker
Jun 5, 2002·Biochimica Et Biophysica Acta·Sławomir Milewski

Related Concepts

Carbohydrate Epimerases
Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing)
Phenotypic Sex
Gonadal Steroid Hormones
Subcellular Fractions
Submandibular Gland

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