PMID: 3748316Jun 1, 1986Paper

Sex difference in reward asymmetry and effects of cocaine

Neuropharmacology
S D Glick, J I Badalamenti

Abstract

Male and female rats with bilaterally implanted electrodes in the lateral hypothalamus were tested daily for self-stimulation of each side of the brain, and rotation (circling behavior) was recorded concomitantly. All rats rotated in a preferred direction, regardless of the side of the brain stimulated, and all rats had asymmetries in the sensitivity for self-stimulation (thresholds and rate-intensity functions) related to the direction of rotation. However, the direction of the asymmetry of self-stimulation was sex-dependent: the side of the brain contralateral to the preferred direction of rotation was the more sensitive side in female rats, as reported previously, whereas the ipsilateral side was the more sensitive side in male rats. In both sexes, cocaine acted predominantly on the contralateral side: that is, cocaine lowered the thresholds and shifted the rate-intensity functions to the left on both sides of the brain, but the effects were much greater on the side of the brain contralateral to the preferred direction of rotation. When compared to baseline parameters, cocaine enhanced the asymmetry of self-stimulation in female rats, but reduced or reversed the asymmetry of self-stimulation in male rats; similar effects wer...Continue Reading

References

Jan 1, 1978·Annual Review of Pharmacology and Toxicology·H C Fibiger
Aug 25, 1978·Brain Research·R A Wise
May 1, 1976·Life Sciences·S D GlickL N Fleisher
May 1, 1975·Pharmacology, Biochemistry, and Behavior·S Greenstein, S D Glick
Jan 1, 1971·Acta Physiologica Scandinavica. Supplementum·U Ungerstedt
Dec 1, 1983·Pharmacology, Biochemistry, and Behavior·R M ShapiroS D Glick
Feb 1, 1984·Brain Research Bulletin·A G Phillips
Jan 1, 1981·Psychopharmacology·S D GlickR C Meibach
Jan 1, 1982·Psychopharmacology·S D GlickR C Meibach

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Citations

Dec 1, 1990·Pharmacology, Biochemistry, and Behavior·F van Haaren, C E Hughes
Sep 1, 1996·Drug and Alcohol Dependence·R M Craft, J A Stratmann
Oct 6, 2001·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·S Pogun
Oct 24, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Dara M CannonWayne C Drevets

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