PMID: 3762572Nov 1, 1986Paper

Sex difference in the micronucleus test. The Collaborative Study Group for the Micronucleus Test

Mutation Research

Abstract

Since sex difference seemed to be one of the most urgent issues to be clarified among many parameters in protocols for the micronucleus test, the collaborative study group for the micronucleus test, consisting of members of the Japanese Environmental Mutagen Society, focused on this subject first. 20 clastogens were examined for sex-related differences of response in the micronucleus test with male and female mice at 20 participating laboratories, one at each laboratory. The results obtained were analyzed and 10 out of the 20 compounds were chosen for further tests for confirmation and re-examination. As a rule, each retested compound was evaluated at 2 laboratories with different strains of mice. The overall results of the first and second trials indicate that (1) all compounds induced micronuclei in both male and female mice, (2) 2-acetylaminofluorene (2-AAF), benzene, benzo[a]pyrene (B[a]P), and 7,12-dimethylbenzanthracene (DMBA) induced significantly higher incidences of micronuclei in males than in females, (3) ethyl methanesulfonate induced more micronuclei in females than in males, and (4) the other compounds showed almost the same responses in males and females or slightly higher responses in males than in females. The ...Continue Reading

References

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Apr 1, 1988·Journal of Applied Toxicology : JAT·M L GarriottA J Kokkino
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Citations

Jan 1, 1990·Environmental and Molecular Mutagenesis·S Sutou, S Sato
Sep 1, 1993·Mutation Research·J D TuckerA V Carrano
Mar 1, 1993·Mutation Research·P Mosesso, F Palitti
Jun 1, 1994·Mutation Research·M HayashiH Shimada
Jan 1, 1988·Mutation Research·M D Shelby
Feb 1, 1990·Mutation Research·R N TamuraJ W Parton
Jul 1, 1987·Mutation Research·P P van BuulA T Natarajan
Jan 1, 1990·Mutation Research·S GhoshG Talukder
May 1, 1991·Mutation Research·Y NagaeH Shimizu
Jul 1, 1992·Mutation Research·P VanparysR Marsboom

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