Sex Difference in Trigeminal Neuropathic Pain Response to Exercise: Role of Oxidative Stress

Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur
Zahra RostamiAli Ghanbari

Abstract

Orofacial chronic neuropathic pain commonly occurs following trigeminal nerve injuries. We investigated whether swimming exercise can reduce trigeminal neuropathic pain through improving antioxidant capacity. Twenty-eight Wistar rats of either sex and 180-220 grams were divided into 4 groups as sham, neuropathy, neuropathy + single bout exercise, and neuropathy + 2 weeks of exercise. Trigeminal neuropathy was carried out through chronic constriction injury (CCI) of infraorbital nerve. Protocols of exercise were included a single bout session (45 minutes) and a 2-week (45 minutes/day/6 days a week) swimming exercise. Mechanical allodynia was detected using Von Frey filaments. The activity of the serum antioxidant enzymes glutathione peroxidase and superoxides dismutase was assayed using ELISA kits. We found that CCI significantly reduced facial pain threshold in both sexes (P < 0.05). Both swimming exercise protocols significantly reduced mechanical allodynia in female rats compared to the sham group; however, only 2 weeks of exercise were significantly effective in male rats. The activity of antioxidant enzyme glutathione peroxidase significantly (P < 0.05) decreased following CCI in female rats against that in the sham group a...Continue Reading

References

Oct 1, 1996·The American Journal of Physiology·P M TiidusM E Houston
Jun 17, 1999·Lancet·C J Woolf, R J Mannion
Dec 11, 1999·Pflügers Archiv : European journal of physiology·P TaulerA Pons
Mar 4, 2000·Sports Medicine·K F Koltyn
Feb 27, 2001·Spinal Cord·D Murphy, D B Reid
Dec 14, 2001·The Journal of Biological Chemistry·Tadahiro NumakawaHiroshi Hatanaka
Sep 12, 2002·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·T YamamotoM Naoi
Mar 5, 2003·Free Radical Biology & Medicine·Consuelo BorrásJosé Viña
Nov 19, 2003·The Journal of Pain : Official Journal of the American Pain Society·W F SternbergR H Gracely
May 26, 2005·Neurosurgical Focus·Jorge L EllerKim J Burchiel
Jun 1, 2005·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·G C Manzoni, P Torelli
Aug 16, 2005·Pain·Jeffrey S Mogil, Mona Lisa Chanda
Sep 27, 2005·Archives of Physical Medicine and Rehabilitation·Marie K Hoeger Bement, Kathleen A Sluka
Feb 24, 2006·Disability and Rehabilitation·K C P Vissers
Sep 25, 2007·The Journal of Pain : Official Journal of the American Pain Society·Karen E KuphalBradley K Taylor
Sep 19, 2008·Medicine and Science in Sports and Exercise·Chad KerksickDarryn Willoughby
Apr 23, 2009·Neuroscience Letters·Marie K Hoeger BementSandra K Hunter
Nov 27, 2009·Stroke; a Journal of Cerebral Circulation·Tzu-Yin ChenChin Hsu
Dec 17, 2009·Medicine and Science in Sports and Exercise·Maria KalafatiDimitris Kouretas
Apr 20, 2010·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·S S Bassuk, J E Manson
Apr 29, 2010·Current Pain and Headache Reports·Rafael Benoliel, Yair Sharav
Aug 25, 2010·Pharmacology, Biochemistry, and Behavior·Aldric T HamaJacqueline Sagen
Nov 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sumita ChakrabartiAlan R Gintzler
Nov 19, 2010·Medicine and Science in Sports and Exercise·Lauren W NewcombDane B Cook
Oct 25, 2011·Molecular Aspects of Medicine·Brooks M HybertsonJoe M McCord
Nov 22, 2011·Pain·Christoph PiehClaas Lahmann
Mar 8, 2012·Journal of Neurochemistry·Fabio Di DomenicoD Allan Butterfield
Jun 2, 2012·Current Neuropharmacology·Dario SiniscalcoVito de Novellis
Sep 20, 2012·European Journal of Applied Physiology·David A RaichlenGregory L Gerdeman
Jul 3, 2013·The Journal of Pain : Official Journal of the American Pain Society·Ricardo KusudaGuilherme Lucas

❮ Previous
Next ❯

Citations

Mar 23, 2021·Autism Research : Official Journal of the International Society for Autism Research·Termara C ParkerJames C McPartland
Nov 9, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Luísa Teixeira-SantosDora Pinho

❮ Previous
Next ❯

Software Mentioned

GraphPad prism
GraphPad

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.