Sex differences in acute relief of abstinence-induced withdrawal and negative affect due to nicotine content in cigarettes

Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
K A Perkins, Joshua L Karelitz

Abstract

Acute cigarette smoking may relieve withdrawal and negative affect due to tobacco abstinence to a greater extent in women versus men. Yet, the relative contribution of the cigarette's nicotine content to this sex difference is not clear. Non-quitting dependent adult smokers (N = 44; 21 males, 23 females) participated in 2 virtually identical sessions, each after abstaining overnight (CO < 10 ppm) and differing only in the nicotine content of the designated cigarette. While blind to brand markings, they consumed a total of 24 puffs in controlled fashion for 2 hr in each session, either from a nicotine (Quest 1, 0.6 mg) or denicotinized (Quest 3, 0.05 mg) cigarette. Withdrawal symptoms were obtained before and after smoking, and negative affect was assessed after each period of cigarette exposure consisting of 6 puffs every 25 min. Men and women did not differ in baseline withdrawal and negative affect due to overnight abstinence, but reductions in each symptom were significantly influenced by the interaction of sex × nicotine/denicotinized cigarette (both p < .05). In men, but not in women, each symptom was generally decreased more by the nicotine versus denicotinized cigarette, and the nicotine cigarette reduced each to a great...Continue Reading

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Citations

Jan 29, 2016·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Suzanne van de NobelenReinskje Talhout
Sep 26, 2015·Addictive Behaviors·Bárbara PiñeiroThomas H Brandon
Oct 4, 2015·Pharmacology, Biochemistry, and Behavior·Scott J Moeller, William W Stoops
Sep 11, 2016·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Philip H SmithSherry A McKee
Mar 10, 2018·American Journal of Epidemiology·Marie-Pierre SylvestreJennifer O'Loughlin
Oct 24, 2017·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Megan M Moran-Santa MariaJane E Joseph
Oct 24, 2017·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Kenneth A PerkinsNicole Kunkle
Jun 22, 2019·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Joanna M StreckStephen T Higgins
Jul 4, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yasmin ZakiniaeizKelly P Cosgrove
Apr 3, 2020·Current Pharmaceutical Design·Antonio Cepeda-Benito
Dec 24, 2019·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Rachel L Denlinger-ApteJennifer W Tidey
Apr 9, 2018·Pharmacological Reports : PR·Leon KosmiderMaciej L Goniewicz
Feb 22, 2021·Drug and Alcohol Dependence·Teresa R FranklinReagan R Wetherill
Mar 22, 2020·Tobacco Control·Alexia Camara-MedeirosJoanna E Cohen
May 27, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Dara G GhahremaniEdythe D London

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