PMID: 108723Mar 14, 1979

Sex differences in behavioral and thermal responses to pargyline and tryptophan

Psychopharmacology
A BiegonD Samuel

Abstract

The effects of parenterally injected pargyline and tryptophan on rectal temperature and behavior have been studied in male and female rats. Pargyline alone (50 mg/kg) produced hypothermia in both sexes. Pargyline (50 mg/kg) followed by low doses (20--50 mg/kg) of tryptophan caused a behavioral syndrome consisting of tremor, hindlimb abduction, forepaw treading, and straub tail. In females, but not in males, hypothermia was potentiated. The same dose of pargyline followed by higher doses (60--150 mg/kg) of tryptophan produced a short hypothermia followed by a dose-dependent behavioral syndrome, hyperthermia, and mortality. On all of these measures, females responded following shorter latencies and lower doses of tryptophan. Both hypothermia and hyperthermia were observed in treated animals following pretreatment with a peripheral decarboxylase inhibitor. The results suggest a complex role for serotonin in thermoregulation. The sex differences observed suggest higher activity of serotonin in female rat brains following the drug treatment, which may be accounted for by a higher utilization rate of tryptophan.

References

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Citations

Jan 1, 1985·Journal of Neural Transmission·M CarlssonA Carlsson
Jul 15, 1980·Experientia·J Roberts, H J Rosenfeld
Sep 10, 1984·Life Sciences·C T FischetteB S McEwen
Jul 1, 1986·Neuropharmacology·S L Dickinson, G Curzon
Dec 1, 1984·Physiology & Behavior·W R Holloway, D H Thor
Sep 1, 1990·Pharmacology, Biochemistry, and Behavior·A Fernández-Guasti, O Picazo
Dec 1, 1991·Pharmacology, Biochemistry, and Behavior·L UphouseM Caldarola-Pastuszka
Oct 1, 1995·Pharmacology, Biochemistry, and Behavior·A F Abdel-FattahH Watanabe
Dec 1, 1984·Journal of Affective Disorders·J A HamiltonS Pinkel
Jan 1, 1988·Progress in Neuro-psychopharmacology & Biological Psychiatry·M Carlsson, A Carlsson
Nov 10, 1998·Biological Psychiatry·D R RubinowC A Roca
Mar 25, 1998·Pharmacology, Biochemistry, and Behavior·S Herges, D A Taylor
Sep 30, 2000·Brain Research. Brain Research Reviews·L Uphouse
Sep 2, 1998·British Journal of Pharmacology·D T Malone, D A Taylor
Jan 1, 1990·Annals of the New York Academy of Sciences·A Biegon
Dec 23, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Annie DuchesneRon M Sullivan
Jan 1, 1986·Annals of the New York Academy of Sciences·L H O'Connor, C T Fischette
May 17, 2005·Pharmacology, Biochemistry, and Behavior·Mohammed ArshaduddinMohammad Tariq
May 12, 2005·Behavioral and Cognitive Neuroscience Reviews·Zenab AminC Neill Epperson
Jun 1, 1988·Australian and New Zealand Journal of Medicine·I C Roberts-ThomsonP R Pannall

Related Concepts

Metazoa
Behavior, Animal
Pargyline Hydrochloride
PMS-Tryptophan
Rats, Laboratory

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