Sex differences in cannabinoid-regulated biology: A focus on energy homeostasis

Frontiers in Neuroendocrinology
Edward J Wagner

Abstract

Considerable strides have been made over the past 20 years in our understanding of the ligands, receptor subtypes, signal transduction mechanisms and biological actions comprising the endocannabinoid system. From the ever-expanding number of studies that have been conducted during this time, it has become increasingly clear that sex differences are the cornerstone of cannabinoid-regulated biology. Available evidence has demonstrated that these sex differences endure in the absence of gonadal steroids, and are modulated by the acute, activational effects of these hormones. This review focuses on select aspects of sexually differentiated, cannabinoid-regulated biology, with a particular emphasis on the control of energy balance. It is anticipated that it will lend impactful insight into the pervasive and diverse disparities in how males and females respond to cannabinoids--from the organismal level down to the molecular level. Additionally, it will furnish a newfound appreciation for the need to recalibrate our thinking in terms of how cannabinoids are used as therapeutic adjuvants for a broad range of clinical disorders and associated comorbidities, including body wasting and obesity.

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Citations

Jul 25, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Giovanni DothelCatia Sternini
Sep 15, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Christina M RuizStephen V Mahler
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Nov 13, 2018·Frontiers in Behavioral Neuroscience·Dicky StruikLiana Fattore
Jul 6, 2018·Frontiers in Molecular Neuroscience·Carolina FabeloEdward J Wagner
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May 1, 2020·Scientific Reports·Alexandra B Moussa-TooksWilliam P Hetrick
Nov 5, 2019·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Martin SládekAlena Sumová
Feb 18, 2021·Physiology·Elisabeth RohbeckTania Romacho
Apr 4, 2021·International Journal of Molecular Sciences·Cassandra GastelumEdward J Wagner
Oct 9, 2020·Cell·Melissa EllermannVanessa Sperandio
Jul 26, 2017·Frontiers in Neuroendocrinology·Georgia BalsevichMatthew N Hill
Aug 21, 2021·Scientific Reports·Joanna Agnieszka Komorowska-MüllerBritta Schürmann

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