Sex differences in cardiac electrophysiology

Canadian Journal of Physiology and Pharmacology
Ursula Ravens

Abstract

Women have a longer QT interval than men, which appears to evolve after puberty suggesting that sex hormones have an influence on cardiac electrophysiology. Sex hormones do in fact regulate cardiac ion channels via genomic and nongenomic pathways. Women are at greater risk for life-threatening arrhythmias under conditions that prolong the QT interval. In addition, women exhibit greater sensitivity to QT interval-prolonging drugs. Female sex has also an impact on propensity to cardiovascular disease, including atrial fibrillation. However, ex vivo recorded atrial action potentials (APs) from female and male patients in atrial fibrillation did not exhibit significant differences in shape, except that APs from women had slower upstroke velocity. It is concluded that sex-related differences should be taken into account not only in the clinics, but also in basic research.

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Citations

May 28, 2019·Progress in Biophysics and Molecular Biology·Francesco Paolo Lo MuzioMichele Miragoli
Dec 17, 2020·Journal of Cardiovascular Pharmacology·Michelangelo PaciJussi T Koivumäki
Apr 1, 2021·Cardiovascular Research·Adela Herraiz-MartínezLeif Hove-Madsen
Jun 12, 2021·Heart Rhythm O2·Hailey J JansenRobert A Rose

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