Sex differences in cardiovascular risk profiles of ischemic stroke patients with diabetes in the Greater Cincinnati/Northern Kentucky Stroke Study

Journal of Diabetes
Tracy E MadsenDawn Kleindorfer

Abstract

The aim of the present study was to compare sex-specific associations between cardiovascular risk factors and diabetes mellitus (DM) among patients with acute ischemic stroke (AIS) in the Greater Cincinnati/Northern Kentucky Stroke Study (GCNKSS). The GCNKSS ascertained AIS cases in 2005 and 2010 among adult (age ≥ 20 years) residents of a biracial population of 1.3 million. Past and current stroke risk factors were compared between those with and without DM using Chi-squared tests and multiple logistic regression analysis to examine sex-specific profiles. There were 3515 patients with incident AIS; 1919 (55%) were female, 697 (20%) were Black, and 1146 (33%) had DM. Among both women and men with DM, significantly more were obese and had hypertension, high cholesterol, and coronary artery disease (CAD) compared with those without DM. For women with AIS, multivariable sex-specific adjusted analyses revealed that older age was associated with decreased odds of having DM (adjusted odds ratio [aOR] 0.88, 95% confidence interval [CI] 0.80-0.98). For women with CAD, the odds of DM were increased (aOR 1.76, 95% CI 1.33-2.32). Age and CAD were not significant factors in differentiating the profiles of men with and without DM. Women wit...Continue Reading

References

Sep 1, 1995·Diabetologia·B Stegmayr, K Asplund
Dec 6, 2003·Stroke; a Journal of Cerebral Circulation·Jennifer E HoUNKNOWN Women's Pooling Project
Feb 6, 2004·Stroke; a Journal of Cerebral Circulation·Brett KisselaJoseph Broderick
Mar 3, 2007·Stroke; a Journal of Cerebral Circulation·Carlo Bruno GiordaUNKNOWN DAI Study Group
Mar 28, 2008·Current Diabetes Reports·Amytis Towfighi, Bruce Ovbiagele
Dec 4, 2010·Stroke; a Journal of Cerebral Circulation·Larry B GoldsteinUNKNOWN Council on Peripheral Vascular Disease, and Interdisciplinary Council on Quality of Care and Outcomes Research
Apr 27, 2013·Stroke; a Journal of Cerebral Circulation·Jane C KhouryBrett M Kissela
Feb 8, 2014·Stroke; a Journal of Cerebral Circulation·Cheryl BushnellUNKNOWN Council for High Blood Pressure Research
Feb 25, 2014·Experimental Neurology·Meaghan Roy-O'Reilly, Louise D McCullough

❮ Previous
Next ❯

Citations

Aug 18, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Rebecca WardAdviye Ergul
Feb 21, 2018·Acta Neuropathologica Communications·Najla KfouryJoshua B Rubin
Mar 22, 2019·Journal of Racial and Ethnic Health Disparities·Dawn M AycockDhruvangi Sharma
Jan 1, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·M Yu Maksimova, A S Airapetova

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.