Sex differences in cocaine self-administration behaviour under long access versus intermittent access conditions.

Addiction Biology
Hajer AlgallalAnne-Noël Samaha

Abstract

Studies in humans suggest that women progress more rapidly from initial cocaine use to addiction. Similarly, female rats can show more incentive motivation for cocaine than male rats do. Most preclinical studies on this issue have used self-administration procedures that provide continuous cocaine access during each session ("long-access" or LgA and "short-access"). However, intermittent access (IntA) cocaine self-administration better models the intermittency of human cocaine use. Here, we compared cocaine use in female and male rats that received ten, daily 6-hour LgA or IntA sessions. Cocaine intake was greatest under LgA, and female LgA rats escalated their intake. Only IntA rats (both sexes) developed locomotor sensitization to self-administered cocaine, and sensitization was greatest in females. Five and 25 days after the last self-administration session, we quantified responding for cocaine (0.083-0.75 mg/kg/infusion) under a progressive ratio (PR) schedule, a measure of motivation for drug. Across conditions, females earned more cocaine infusions than males under the PR schedule. Across sexes, IntA rats earned more infusions than LgA rats, even though IntA rats had previously taken much less cocaine. Cumulative cocaine ...Continue Reading

References

Apr 1, 1991·Journal of Neurochemistry·H T PanJ B Justice
Feb 1, 1989·Archives of General Psychiatry·M L GriffinU Lange
Feb 1, 1986·Archives of General Psychiatry·F H Gawin, H D Kleber
Mar 16, 1984·European Journal of Pharmacology·S D Glick, P A Hinds
Sep 1, 1993·Brain Research. Brain Research Reviews·T E Robinson, K C Berridge
Jan 1, 1993·Journal of Substance Abuse Treatment·T A KostenB J Rounsaville
Oct 1, 1996·The Journal of Nervous and Mental Disease·J R McKayA I Alterman
Aug 1, 1997·Journal of Pharmaceutical Sciences·S DuttaW F Ebling
Aug 1, 1997·Psychopharmacology·A S WardR W Foltin
Jul 1, 1999·The Psychiatric Clinics of North America·K T Brady, C L Randall
Dec 22, 1999·The American Journal on Addictions·E F McCance-KatzB J Rounsaville
Feb 9, 2000·Psychopharmacology·W J Lynch, M E Carroll
Jun 22, 2001·The American Journal of Drug and Alcohol Abuse·I ElmanD R Gastfriend
Sep 5, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ming HuJill B Becker
Jan 22, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S Barak CaineNancy K Mello
Feb 12, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Wendy J Lynch, Jane R Taylor
Jun 29, 2004·Pharmacology, Biochemistry, and Behavior·Megan E Roth, Marilyn E Carroll
Aug 16, 2005·Biological Psychiatry·Carrie R FerrarioTerry E Robinson
Mar 1, 2006·Experimental and Clinical Psychopharmacology·Wendy J Lynch
Oct 13, 2006·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Carrie R Ferrario, Terry E Robinson
Oct 2, 2007·Frontiers in Neuroendocrinology·Jill B Becker, Ming Hu
Jul 22, 2008·Biological Psychiatry·David BelinVéronique Deroche-Gamonet
Mar 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Bronwen MartinMark P Mattson
Aug 19, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Benjamin A ZimmerDavid C S Roberts
Mar 29, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Benjamin A ZimmerDavid Cs Roberts
Jun 9, 2012·Biology of Sex Differences·Jill B BeckerChristel Westenbroek
Aug 8, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ellie-Anna MinogianisAnne-Noël Samaha
Mar 19, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Elena Martín-GarcíaVéronique Deroche-Gamonet
Jul 30, 2014·Proceedings of the National Academy of Sciences of the United States of America·Brandon S BentzleyGary Aston-Jones
Sep 13, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Erin S CalipariSara R Jones
Jun 28, 2015·Neuroscience and Biobehavioral Reviews·Florence AllainAnne-Noël Samaha
Jan 17, 2016·Pharmacological Reviews·Jill B Becker, George F Koob
Feb 3, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Donna L Maney
Jul 29, 2016·Biology of Sex Differences·Jill B BeckerJing W Liang

❮ Previous
Next ❯

Citations

Jul 19, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Florence AllainAnne-Noël Samaha
Mar 17, 2020·Cellular and Molecular Life Sciences : CMLS·Brooke N Bender, Mary M Torregrossa
Nov 11, 2020·Scientific Reports·Nazzareno CannellaRainer Spanagel
Apr 25, 2021·Trends in Neurosciences·Anne-Noël SamahaTerry E Robinson
Apr 29, 2021·Psychopharmacology·Eleanor Blair TowersWendy J Lynch

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.