Sex differences in conditioned nicotine reward are age-specific.

Pharmacology, Biochemistry, and Behavior
Magalie LenoirSari Izenwasser

Abstract

Women constitute half of all smokers and many studies suggest that adult males and females differ in factors that maintain tobacco smoking, yet there is limited information about sex differences in nicotine reward during adolescence. Limited studies suggest that adolescent male rats self-administer more nicotine than adults, suggesting that drug administration during adolescence leads to different behavioral effects than during adulthood. In the present study, male rats developed a significant conditioned place preference (CPP) to lower doses of nicotine than females, regardless of age. In addition, adolescents were more sensitive than adults. In female rats, adolescents exhibited a CPP of greater magnitude than adult females. In males, the magnitude of the CPP did not differ as a function of age, but adolescents exhibited CPP to lower doses than adults. There also were differences in nicotinic acetylcholinergic receptor binding in nucleus accumbens and caudate putamen in response to nicotine across age and sex. These findings suggest that it is necessary to consider sex- and age-specific effects of drugs such as nicotine when developing strategies for improving smoking cessation treatments.

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Citations

May 29, 2015·The Journal of Physiology·Menglu YuanFrances M Leslie
Apr 29, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Oscar V Torres, Laura E O'Dell
Nov 26, 2015·Frontiers in Neuroscience·Manoranjan S D'Souza
Aug 4, 2016·Brain Research·Stephanie Collins Reed, Sari Izenwasser
Apr 6, 2017·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Tracy T SmithAlan F Sved
Nov 20, 2018·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Song XueAdriaan W Bruijnzeel
Oct 23, 2019·Translational Neuroscience·Jing LiuRongbo Zhang
Nov 22, 2016·Journal of Neuroscience Research·Sakire PogunLutfiye Kanit
Jan 15, 2016·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Rachel L SchassburgerAlan F Sved
Nov 22, 2016·Journal of Neuroscience Research·Sarah J CrossFrances M Leslie
May 15, 2021·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Ranjithkumar ChellianAdriaan W Bruijnzeel

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