Sex differences in DEK expression in the anterior cingulate cortex and its association with dementia severity in schizophrenia

Schizophrenia Research
Sinead M O'DonovanMatia B Solomon

Abstract

DEK is a chromatin-remodeling phosphoprotein found in most human tissues, but its expression and function in the human brain is largely unknown. DEK depletion in vitro induces cellular and molecular anomalies associated with cognitive impairment, including down-regulation of the canonical Wnt/β-catenin signaling pathway. ToppGene analyses link DEK loss to genes associated with various dementias and age-related cognitive decline. To examine the role of DEK in cognitive impairment in severe mental illness, DEK protein expression was assayed by immunoblot in the anterior cingulate cortex (ACC) of subjects with schizophrenia. Cognitive impairment is a core feature of schizophrenia and cognitive function in subjects was assessed antemortem using the clinical dementia rating (CDR) scale. DEK protein expression was not significantly altered in schizophrenia (n = 20) compared to control subjects (n = 20). Further analysis revealed significant reduction in DEK protein expression in women with schizophrenia, and a significant increase in expression in men with schizophrenia, relative to their same-sex controls. DEK protein expression levels were inversely correlated with dementia severity in women. Conversely, in men, DEK protein express...Continue Reading

References

Aug 27, 1998·Schizophrenia Bulletin·P PowchikK L Davis
Nov 25, 2003·Nucleic Acids Research·Tanja WaldmannClaudia Gruss
Mar 10, 2004·International Review of Neurobiology·Robert E McCullumsmithJames H Meador-Woodruff
Mar 11, 2004·Acta Psychiatrica Scandinavica·T J HuberH M Emrich
May 3, 2005·Psychopharmacology·Alessandro GuidottiErminio Costa
May 27, 2005·PLoS Medicine·Dinesh Bhugra
Sep 24, 2005·Genes, Chromosomes & Cancer·Marija OrlicBrenda L Gallie
Sep 29, 2005·The Journal of Clinical Psychiatry·Eric Q WuJyoti Aggarwal
Sep 15, 2007·Molecular Cancer Research : MCR·Martín C AbbaC Marcelo Aldaz
Feb 21, 2009·Journal of Cellular Biochemistry·Dong-Wook KimSang-Beom Seo
Dec 1, 2006·Neuropsychiatric Disease and Treatment·Christopher R Bowie, Philip D Harvey
Jul 1, 2009·Pathology International·Songying HanZhenhua Lin
May 11, 2010·Schizophrenia Research·Nicola G CascellaDavid J Schretlen
Jun 24, 2010·Biological Psychiatry·Meredith A ReidAdrienne C Lahti
Jan 1, 2006·Indian Journal of Psychiatry·J K Trivedi
Nov 26, 2010·Progress in Brain Research·Doodipala Samba Reddy
Feb 19, 2011·Nature Reviews. Neuroscience·Alexander J ShackmanRichard J Davidson
Jun 10, 2011·Nucleic Acids Research·Gina M KavanaughSusanne I Wells
Aug 25, 2011·The Psychiatric Quarterly·Jharna N ShahPaul E Schulz
Dec 14, 2011·Briefings in Functional Genomics·Marquis P VawterFabio Macciardi
Jan 10, 2012·Trends in Cognitive Sciences·Clay B Holroyd, Nick Yeung
May 11, 2012·Current Opinion in Neurobiology·Matthew F S RushworthRogier B Mars
Oct 17, 2012·PloS One·Lisa M Privette VinnedgeSusanne I Wells
Jan 15, 2013·Neuroscience and Biobehavioral Reviews·Philip Gerard Gasquoine
Aug 22, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·L Felice ReddyMichael F Green
Sep 17, 2013·Cell Reports·Ying TanRonald L Davis
Sep 5, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ye ZhangJian Qian Wu
Dec 2, 2014·Psychological Review·Clay B Holroyd, Samuel M McClure
Mar 15, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Robert E McCullumsmithJames H Meador-Woodruff
Apr 1, 2015·PloS One·Courtney R SullivanRobert E McCullumsmith
Jun 10, 2015·Translational Psychiatry·S M O'DonovanR E McCullumsmith
Oct 8, 2015·JAMA Psychiatry·Anette Riisgaard RibeMogens Vestergaard
Mar 31, 2016·Asia-Pacific Psychiatry : Official Journal of the Pacific Rim College of Psychiatrists·Hyemin KuJin-Won Kwon
Sep 28, 2016·Nature Neuroscience·Nils KollingMatthew F S Rushworth
Oct 30, 2016·Neuroscience and Biobehavioral Reviews·Clay B Holroyd, Akina Umemoto

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Dec 12, 2020·Frontiers in Molecular Neuroscience·Allie N GreeneLisa M Privette Vinnedge

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