Sex differences in depression-like behavior after nerve injury are associated with differential changes in brain-derived neurotrophic factor levels in mice subjected to early life stress

Neuroscience Letters
Takashi NishinakaShogo Tokuyama

Abstract

We recently demonstrated that exposure to early life stress exacerbates nerve injury-induced thermal and mechanical hypersensitivity in adult male and female mice. Accumulating evidence suggests that chronic pain causes emotional dysfunction, such as anxiety and depression. In the present study, we investigated the impact of early life stress on depression-like behavior after nerve injury in mice. In addition, we examined the expression of brain-derived neurotrophic factor (BDNF), which is known to be involved in the pathogenesis of depression. Early life stress was induced by maternal separation between 2 and 3 weeks of age combined with social isolation after weaning (MSSI). At 9 weeks of age, the sciatic nerve was partially ligated to elicit neuropathic pain. Depression-like behavior was evaluated using the forced swim test at 12 weeks of age. Tissue samples from different regions of the brain were collected at the end of maternal separation (3 weeks of age) or after the forced swim test (12 weeks of age). At 12 weeks of age, immobility time in the forced swim test was increased only in MSSI-stressed female mice with nerve injury. BDNF expression was increased in male, but not female, MSSI-stressed mice at 3 weeks of age. Ho...Continue Reading

References

Mar 6, 2004·Neuromolecular Medicine·Ronald S Duman
Aug 27, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Minoru NaritaTsutomu Suzuki
Jul 8, 2008·The Journal of Pain : Official Journal of the American Pain Society·Adley TsangMakoto Watanabe
Aug 30, 2008·Journal of Neurochemistry·Erika TothAbraham Zangen
Apr 1, 2009·Journal of Trauma & Dissociation : the Official Journal of the International Society for the Study of Dissociation (ISSD)·Natalie Sachs-EricssonKathleen Kendall-Tackett
Dec 5, 2009·European Journal of Pain : EJP·Pascal VanelderenKris Vissers
Aug 21, 2010·Nature Reviews. Neuroscience·Daniel A HackmanMichael J Meaney
Oct 19, 2010·The International Journal of Neuropsychopharmacology·Minae NiwaToshitaka Nabeshima
Nov 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shusaku UchidaYoshifumi Watanabe
Mar 25, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dekel TaliazAbraham Zangen
Jun 30, 2011·Neuropharmacology·Rita J ValentinoDebra Bangasser
Aug 9, 2011·Behavioural Brain Research·A KorosiP J Lucassen
Sep 6, 2011·Biological Psychiatry·Ipek YalcinMichel Barrot
Nov 15, 2011·Trends in Cognitive Sciences·Ilia N Karatsoreos, Bruce S McEwen
Jan 17, 2012·Behavioural Brain Research·Alexandre J ParentLouis Gendron
Apr 28, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Amelia A MutsoA Vania Apkarian
Jul 4, 2012·The Journal of Clinical Investigation·Hyangin KimJianren Mao
Feb 22, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maryna BaydyukBaoji Xu
Apr 17, 2013·Pflügers Archiv : European journal of physiology·Nina C Donner, Christopher A Lowry
May 22, 2013·Translational Neuroscience·Cheng Jiang, Stephen R Salton
Jul 16, 2013·The Journal of Pain : Official Journal of the American Pain Society·Nikita N BurkeMichelle Roche
Nov 29, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yossef GofferJing Wang

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Citations

Feb 3, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Laurne S TerasakiJaclyn M Schwarz
Dec 10, 2015·Frontiers in Behavioral Neuroscience·Paola CaporaliLaura Petrosini
Nov 14, 2015·Journal of Cellular Physiology·Shengyu WangY S Prakash
Oct 27, 2016·Neuroscience·Meggane MelchiorSerge Marchand
Jun 23, 2016·Neuroscience and Biobehavioral Reviews·Saulo G TractenbergRodrigo Grassi-Oliveira
Apr 9, 2016·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Dokyoung S YouMary W Meagher
Feb 23, 2020·International Journal of Molecular Sciences·Zhuang MiaoZhongsheng Sun
Sep 2, 2016·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Takashi NishinakaShogo Tokuyama
Feb 28, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Dao H HoJennifer S Pollock
Dec 15, 2016·Journal of Biosciences·Natalya P Bondar, Tatiana I Merkulova
Nov 22, 2016·Journal of Neuroscience Research·Yi-Chao WeiXiao-Hong Xu
Sep 28, 2020·Neuroscience and Biobehavioral Reviews·Ana Margarida CunhaHugo Leite-Almeida

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