Sex differences in diaphragmatic fatigue: the cardiovascular response to inspiratory resistance

The Journal of Physiology
Joseph F WelchA William Sheel

Abstract

Diaphragmatic fatigue (DF) elicits a sympathetically mediated metaboreflex resulting in increased heart rate, blood pressure and limb vascular resistance. Women may be more resistant to DF compared to men, and therefore it was hypothesised that women would experience an attenuated inspiratory muscle metaboreflex during inspiratory pressure-threshold loading (PTL) performed to task failure. At the time of PTL task failure, the severity of DF was not different between sexes; however, inspiratory muscle endurance time was significantly longer in women than in men. For a given cumulative diaphragmatic force output, the severity of DF was less in women than in men. Women exhibited a blunted cardiovascular response to inspiratory resistance (i.e. metaboreflex) that may have implications for exercise tolerance. Diaphragmatic fatigue (DF) elicits reflexive increases in sympathetic vasomotor outflow (i.e. metaboreflex). There is some evidence suggesting women may be more resistant to DF compared to men, and therefore may experience an attenuated inspiratory muscle metaboreflex. To this end, we sought to examine the cardiovascular response to inspiratory resistance in healthy young men (n = 9, age = 24 ± 3 years) and women (n = 9, age = ...Continue Reading

References

Nov 1, 1977·The Journal of Physiology·R H EdwardsP A Merton
Aug 1, 1977·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·C S Roussos, P T Macklem
Aug 1, 1991·Circulation·A MallianiS Cerutti
Sep 1, 1990·Journal of Applied Physiology·S N HussainC Roussos
Sep 1, 1988·The American Review of Respiratory Disease·G SupinskiM Altose
Jan 1, 1987·Journal of Applied Physiology·H BarkS G Kelsen
Mar 1, 1986·Journal of Applied Physiology·P A Barnard, S Levine
Jan 1, 1985·Journal of Applied Physiology·B BuchlerC Roussos
Feb 1, 1973·Journal of Applied Physiology·D A LiebermanL C Maxwell
Jul 1, 1981·Acta Physiologica Scandinavica·E Nygaard
May 1, 1997·Journal of Applied Physiology·C A HarmsJ A Dempsey
Jun 1, 1997·Journal of Applied Physiology·D K McKenzieS C Gandevia
Aug 13, 1999·Journal of Applied Physiology·P HaouziM P Kaufman
Dec 2, 2000·The Journal of Physiology·C M St CroixJ A Dempsey
Jul 28, 2001·Exercise and Sport Sciences Reviews·A L HicksD S Ditor
Apr 19, 2002·Journal of Applied Physiology·Aaron Aaker, M H Laughlin
Aug 21, 2002·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society/European Respiratory Society
Feb 4, 2003·Journal of Applied Physiology·David W Russ, Jane A Kent-Braun
May 20, 2003·Journal of Applied Physiology·Joshua R RodmanJerome A Dempsey
Feb 18, 2004·Journal of Applied Physiology·Sandra K HunterRoger M Enoka
Mar 16, 2005·Hypertension·Krzysztof NarkiewiczVirend K Somers
Mar 17, 2006·Medicine and Science in Sports and Exercise·Joaquin U Gonzales, Barry W Scheuermann
Apr 18, 2006·Respiratory Physiology & Neurobiology·Jerome A DempseyCurtis Smith
Sep 5, 1919·The Journal of Physiology·H W DaviesJ G Priestley
May 28, 2009·Hypertension·Emma C HartNisha Charkoudian
Jun 25, 2009·Exercise and Sport Sciences Reviews·Sandra K Hunter
Mar 12, 2010·European Journal of Applied Physiology·Samuele Maria Marcora, Walter Staiano
Apr 24, 2010·Journal of Applied Physiology·Jordan A GuenetteA William Sheel
Jan 21, 2015·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Meaghan J MacNuttA William Sheel
Jan 23, 2016·Medicine and Science in Sports and Exercise·Andrew H RamsookJordan A Guenette
Aug 5, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Joshua R SmithCraig A Harms
Oct 28, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mark B BadrovJ Kevin Shoemaker
Nov 4, 2016·European Journal of Sport Science·Mark Burnley, Andrew M Jones
May 6, 2017·Journal of Applied Physiology·Timothy P Just, Darren S DeLorey
Aug 12, 2017·Experimental Physiology·Jill N Barnes

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Citations

Jul 5, 2018·The Journal of Physiology·Timothy David Noakes
Sep 29, 2018·The Journal of Physiology·Claire M DeLucia, Daniel H Craighead
Oct 12, 2018·Journal of Applied Physiology·Joseph F WelchA William Sheel
Mar 1, 2019·Exercise and Sport Sciences Reviews·Paolo B DominelliA William Sheel
Sep 24, 2020·The Journal of Physiology·Paul AnsdellStuart Goodall
Nov 13, 2020·The Journal of Physiology·Bruno ArchizaA William Sheel
Dec 29, 2020·Journal of Applied Physiology·Tim A HardyBryan J Taylor
Sep 11, 2020·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Andrew H RamsookJordan A Guenette
Apr 28, 2021·Physiological Reports·Fernando G BeltramiChristina M Spengler
Apr 28, 2021·European Journal of Applied Physiology·Bruno ArchizaA William Sheel
Oct 17, 2020·Medicine and Science in Sports and Exercise·Timothy J FultonRobert F Chapman
May 4, 2021·Physiological Reports·William MacAskillDean E Mills
Oct 19, 2021·Frontiers in Physiology·Maximiliano Espinosa-RamírezFelipe Contreras-Briceño
Jan 14, 2022·European Respiratory Review : an Official Journal of the European Respiratory Society·Paolo B Dominelli, Yannick Molgat-Seon

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