Sex differences in effects of mild chronic stress on seizure risk and GABAA receptors in rats

Pharmacology, Biochemistry, and Behavior
Ritu Chadda, Leslie L Devaud

Abstract

Social stress is a common occurrence in our society that can negatively impact health. Therefore, we wanted to study the effects of a mild stressor designed to model social stress on seizure susceptibility and GABAA receptors in male and female rats. The mild chronic stress of individual housing consistently decreased bicuculline (but not pentylenetetrazol, PTZ) seizure thresholds by 10-15% in both sexes. Housing conditions did not alter the anticonvulsant activity of diazepam or ethanol, although the anticonvulsant effect of ethanol was significantly greater against PTZ-induced seizures. Experiments testing the addition of an acute restraint stress unmasked sex differences in seizure induction. The acute stress also selectively decreased the potency of GABA to modulate GABAA receptor-mediated chloride uptake in group-housed females. There were additional sex differences by housing condition for GABAA receptor-gated chloride uptake but no differences in [3H]flunitrazepam binding. We also found significant effects of sex and housing on ethanol-induced increases in corticosterone (CORT) levels. In summary, there were complex and sex-selective effects of mild chronic stress on seizure induction and GABAA receptors. Gaining a bette...Continue Reading

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Citations

Oct 26, 2005·Naunyn-Schmiedeberg's Archives of Pharmacology·Romana Slamberová, R Rokyta
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Jun 18, 2014·Frontiers in Cellular Neuroscience·Jamie Maguire
Jul 26, 2005·Pharmacology, Biochemistry, and Behavior·Ritu Chadda, Leslie L Devaud
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Feb 15, 2013·Journal of Preventive Medicine and Public Health = Yebang Ŭihakhoe Chi·Kyusik ChoiHae-Kwan Cheong
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May 1, 2021·International Journal of Molecular Sciences·Claudia Espinosa-GarciaAsheebo Rojas
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Jul 1, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Rajan NikbakhshAhmad Reza Dehpour
Jul 20, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Faiza MumtazAhmad Reza Dehpour

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