Sex Differences in Estradiol Secretion by Trigeminal Brainstem Neurons

Frontiers in Integrative Neuroscience
D A BereiterM Rahman

Abstract

Estrogen status is a significant risk factor in the development of temporomandibular joint disorders (TMD). Classically, estrogen status is thought to derive mainly from ovarian sources; however, it is well known that estradiol (E2) also is synthesized by neurons in the brain. This study tested the hypothesis that E2 is produced by neurons in trigeminal subnucleus caudalis (Vc), the principal site of termination for sensory afferents that supply the temporomandibular joint (TMJ), to modify evoked responses in a model of TMJ nociception in male and female rats. Intra-TMJ injection of the small fiber excitant, allyl isothiocyanate (AIC), increased the levels of E2 collected from microdialysis probes sites at Vc of ovariectomized (OvX) female rats, ipsilateral to the stimulus, whereas males displayed no change. Dialysate levels of E2 collected from probe sites in the contralateral Vc or cerebellum in OvX rats were not affected by TMJ stimulation. Reverse dialysis of anastrozole, an aromatase (ARO) inhibitor, via the probe reduced perfusate levels of E2 in Vc. Systemic administration of letrozole, a non-steroid ARO inhibitor, for 4 days prevented TMJ-evoked increases in masseter muscle electromyography (MMemg) activity. ARO-positiv...Continue Reading

References

Feb 27, 1999·Journal of Neuroendocrinology·T L Horvath, K C Wikler
Nov 19, 2003·The Journal of Steroid Biochemistry and Molecular Biology·E R Simpson
Dec 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yasushi HojoSuguru Kawato
Aug 20, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Henry C Evrard, Jacques Balthazart
Jun 17, 2006·Pain·Luda DiatchenkoWilliam Maixner
Aug 18, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Henry C Evrard
Aug 22, 2006·Annual Review of Pharmacology and Toxicology·Catherine S Woolley
May 19, 2007·Cranio : the Journal of Craniomandibular Practice·Barry C Cooper, Israel Kleinberg
Oct 24, 2007·Pain·Rebecca M Craft
Mar 29, 2008·The European Journal of Neuroscience·Julia KuhnTim Hucho
Sep 30, 2008·Nature Neuroscience·Luke Remage-HealeyBarney A Schlinger
May 5, 2009·The Journal of Pain : Official Journal of the American Pain Society·Roger B FillingimJoseph L Riley
May 7, 2009·Frontiers in Neuroendocrinology·Paul Micevych, Reymundo Dominguez
Nov 17, 2009·Brain Research·Keiko TakanamiMitsuhiro Kawata
May 19, 2010·Progress in Brain Research·Wah Chin BoonEvan R Simpson
Jul 22, 2010·The Journal of Pharmacology and Experimental Therapeutics·Matthew P RowanWilliam P Clarke
Jun 29, 2011·International Review of Neurobiology·David A Bereiter, Keiichiro Okamoto
Nov 8, 2011·Journal of Dental Research·A TashiroD A Bereiter
Nov 11, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Deepak P SrivastavaFeng Liu
Jun 16, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ricardo VierkGabriele M Rune
Aug 21, 2012·Neurochemical Research·Yan ZhangYu-Qiu Zhang
Jan 26, 2013·Trends in Molecular Medicine·Jie CuiRena Li
Mar 5, 2013·The Journal of Pain : Official Journal of the American Pain Society·Qiuling ShiCharles S Cleeland
Jul 3, 2013·Frontiers in Neuroendocrinology·Åsa Amandusson, Anders Blomqvist
Sep 12, 2013·American Journal of Physiology. Endocrinology and Metabolism·Mayur J PatilArmen N Akopian
Dec 7, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Brian P KenealyEi Terasawa

❮ Previous
Next ❯

Citations

Jun 26, 2020·Journal of Pain Research·Petra Tariba KneževićSunčana Simonić-Kocijan

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
Assay

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.