PMID: 39835Jul 1, 1978

Sex differences in fetal sheep adrenal steroidogenesis

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
J Ayromlooi, W B Essman


The formation of several steroids was determined in vitro in adrenals removed from 18 female and six male fetuses of 113-115 days' gestation and in two female and two male fetuses at near term (137-143 days). Samples were incubated with 14C-acetate and the formation of labeled steroids was determined by two-dimensional paper chromatography. Protein and corticosterone concentrations were determined by chromophore absorption and acid hydrolysis fluorescence methods, respectively. Tissue corticosterone concentrations were significantly higher in female (0.145 +/- 0.010 microgram/mg protein) than in male (0.083 +/- 0.010 microgram/mg protein) adrenal tissue at both stages, whereas corticosterone formation was similar in both sexes. Cholesterol formation was significantly higher in female (0.103 +/- 0.079 muM/mg protein) than in male (0.044 +/- 0.011 muM/mg protein) adrenals at both stages. Both testosterone and estradiol were synthesized at higher rates in female than in male adrenals (52% and 33%, respectively), whereas pregnanediol formation was 21% higher in the male. These results indicate that significant sex differences exist in the formation of various adrenocortical hormones by fetal tissues. The relevance of these findings...Continue Reading


Jan 15, 1974·American Journal of Obstetrics and Gynecology·P A Baird, R B Lowry
Feb 15, 1968·American Journal of Obstetrics and Gynecology·B LeducR Simard
Apr 1, 1970·Radiology·A K PoznanskiJ C Gall
Jan 1, 1967·Acta Obstetricia Et Gynecologica Scandinavica·A Turunen, C E Unnérus

Related Concepts

Corticosterone Assay
Testosterone Measurement
Fetal Structures
Cholesterol Biosynthetic Process
Estradiol, (16 alpha,17 beta)-Isomer
Estradiol Measurement
Dall Sheep
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