Sex differences in flow cytometry-based platelet reactivity in stable outpatients suspected of myocardial ischemia

Research and Practice in Thrombosis and Haemostasis
Farahnaz WaissiLeo Timmers

Abstract

Antiplatelet therapy is the mainstay of secondary prevention of cardiovascular events. Studies suggest that women do not obtain equal therapeutic benefit from antiplatelet therapy compared with men. The link between sex differences in platelet biology and response to antiplatelet therapies is unclear. We therefore investigated the role of sex differences in platelet reactivity in a cohort of outpatients with chest pain, in response to treatment with antiplatelet agents. Platelet reactivity was measured in 382 randomly selected patients participating in the Myocardial Ischemia Detection by Circulating Biomarkers (MYOMARKER) study, an observational cohort study of outpatients suspected of myocardial ischemia. In all patients, blood was collected during diagnostic workup, and platelet reactivity was assessed with a flow cytometry-based platelet activation test that quantifies both platelet degranulation (P-selectin expression) and platelet aggregation (fibrinogen binding to integrin αIIbβ3) in whole blood. Platelet reactivity was higher in women compared with men when activated with protease activating receptor 1-activating peptide SFLLRN (PAR1-AP) and adenosine 5'-phosphate (ADP), independent of age, basal activation status, esti...Continue Reading

References

Sep 25, 2002·Journal of Internal Medicine·P JäremoA Richter
Dec 14, 2004·Clinical Pharmacology and Therapeutics·Zourab BebiaRobert A Branch
Mar 23, 2006·JAMA : the Journal of the American Medical Association·Diane M BeckerNauder Faraday
Mar 7, 2009·Journal of the American College of Cardiology·Dirk SibbingNicolas von Beckerath
Nov 17, 2009·Journal of the American College of Cardiology·Jeffrey S BergerPeter B Berger
Jul 9, 2011·Stroke; a Journal of Cerebral Circulation·Guus W van LammerenGert Jan de Borst
Sep 9, 2011·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·N J BreetJ M Ten Berg
Oct 30, 2015·Journal of Thrombosis and Haemostasis : JTH·Monica VerdoiaGiuseppe De Luca
Feb 13, 2016·Cardiovascular Drugs and Therapy·Monica VerdoiaUNKNOWN Novara Atherosclerosis Study Group (NAS)
Nov 22, 2016·The International Journal of Angiology : Official Publication of the International College of Angiology, Inc·Tesse C LeunissenMark Roest
Mar 25, 2017·Journal of the American College of Cardiology·Emily S LauMichelle L O'Donoghue
Jan 18, 2018·Journal of Thrombosis and Haemostasis : JTH·I van AstenR T Urbanus
Sep 11, 2019·European Heart Journal·Juhani KnuutiUNKNOWN ESC Scientific Document Group

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Methods Mentioned

BETA
fluorescence activated cell sorting
coronary artery bypass
blood collection
dissection

Software Mentioned

SPSS
FACSDiva

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