Sex differences in frailty and its association with low bone mineral density in rheumatoid arthritis.

Bone Reports
Katherine D WyshamPatricia P Katz

Abstract

Frailty in the general population is associated with poor health outcomes including low bone mass and osteoporotic fracture. The relationship between frailty and low bone mineral density (BMD) in rheumatoid arthritis (RA) is unknown. This study examined associations between frailty and BMD in RA, controlling for established osteoporosis risk factors. We performed a cross-sectional analysis of a longitudinal RA cohort (n = 138; 117 female, 21 male). Participants fulfilled ACR RA classification criteria. Frailty was evaluated using the Fried Index, categorizing each participant as robust, pre-frail or frail. To identify independent predictors of BMD, we performed a multivariable linear regression analysis. Because risk factors for low BMD differ between sexes, we performed additional sex-stratified multivariable analyses. Mean age and disease duration were 58.0 ± 10.8 and 19 ± 10.9 years, respectively. The majority of participants were categorized as pre-frail (70%) or frail (10%). Females had higher rates of frailty than males. In the whole cohort, both pre-frail and frail had independent negative associations with BMD (β = -0.074 and -0.092 respectively, p < 0.05). In sex-stratified analyses, frailty did not have a significant ...Continue Reading

Citations

Mar 3, 2021·Current Opinion in Rheumatology·Katherine D WyshamDolores M Shoback
Sep 3, 2021·The Journal of Rheumatology·Sarah B LieberLisa A Mandl
Jan 17, 2022·Joint, Bone, Spine : Revue Du Rhumatisme·Rui-Chen GaoGuo-Cui Wu

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BETA
ESR

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Stata
Lunar Prodigy DXA
RADAI

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