Sex differences in functional connectivity in first-episode and chronic schizophrenia patients

The American Journal of Psychiatry
Shameran Slewa-YounanLeanne M Williams

Abstract

There has been consistent evidence for a lower incidence and milder course of schizophrenia in women, yet there have been very few investigations of sex differences in brain function in this disorder. This study used a new high-temporal-resolution measure of functional brain connectivity to test the prediction that female patients would show relatively greater inter- and intrahemispheric connectivity than male patients, particularly in the early stage of schizophrenia. Forty patients with chronic schizophrenia (20 women and 20 men) and 24 patients with first-episode schizophrenia (12 women and 12 men) and their respective matched comparison groups completed a conventional auditory oddball task. Phase synchronous gamma (40 Hz) activity was extracted from EEG recording during the task and time-locked to the oddball (target) stimuli. Chronic schizophrenia subjects showed a reduction in global functional connectivity (lower gamma phase synchrony) relative to their matched healthy subjects. Unexpectedly, this reduction was most apparent in female patients. By contrast, while first-episode patients showed a general reduction in the speed of frontal connectivity, the speed of global connectivity was relatively faster in female patient...Continue Reading

Citations

Apr 5, 2012·Archives of General Psychiatry·Fabio FerrarelliGiulio Tononi
Sep 10, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michael J MinzenbergCameron S Carter
Dec 2, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Christine E MarxJeffrey A Lieberman
Jul 31, 2013·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Erol Başar
Nov 24, 2012·Asian Journal of Psychiatry·Deepshikha Ray, Daya Ram
May 25, 2010·Psychiatry Research·Sidse Marie Hemmingsen ArnfredJosef Parnas
Jul 8, 2008·Schizophrenia Research·Gary FlynnLeanne M Williams
Jan 13, 2006·Annals of Neurology·Anthony B WaitesGraeme D Jackson
Sep 12, 2006·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Canan Basar-ErogluChristina Schmiedt
Aug 1, 2006·Schizophrenia Research·Sifis MicheloyannisMichael Zervakis
Mar 22, 2014·Cerebral Cortex·Theodore D SatterthwaiteRuben C Gur
Oct 20, 2009·Neuroscience and Biobehavioral Reviews·Wolfgang KlimeschPaul Sauseng
Jan 27, 2015·Frontiers in Psychology·Johann IssartelLudovic Marin
Aug 23, 2008·Thérapie·Jean-Pierre Olié
Apr 30, 2011·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Gaolang GongAlan C Evans
Dec 5, 2014·Journal of Neural Engineering·Alejandro BachillerRoberto Hornero
Apr 16, 2018·Neuroscience and Biobehavioral Reviews·Thomas J ReillyPhilip McGuire
May 22, 2021·Frontiers in Psychiatry·Andrea PerrottelliArmida Mucci

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