Sex differences in hypothalamic-pituitary-adrenal axis regulation after chronic unpredictable stress.

Brain and Behavior
Michelle C PalumboHongxin Dong

Abstract

Exposure to stress, mediated through the hypothalamic-pituitary-adrenal (HPA) axis, elicits sex differences in endocrine, neurological, and behavioral responses. However, the sex-specific factors that confer resilience or vulnerability to stress and stress-associated psychiatric disorders remain largely unknown. The evident sex differences in stress-related disease prevalence suggest the underlying differences in the neurobiological underpinnings of HPA axis regulation. Here, we used a chronic unpredictable stress (CUS) model to investigate the behavioral and biochemical responses of the HPA axis in C57BL/6 mice. Animals were tested in the open field and forced swim test to examine anxiety-like and depressive-like behaviors. Plasma corticosterone levels were measured after behavior and CUS, and glucocorticoid receptor (GR) expression and cytosolic and nuclear fractions of binding protein FKBP51 expression were taken to measure function and regulation of the stress response. Our results indicate increased depressive-like behavior in males and females which correlated with increased corticosterone levels following CUS. However, females displayed more anxiety-like behaviors with and without CUS. Interestingly, we found trends towa...Continue Reading

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Citations

Jan 1, 2021·International Journal of Molecular Sciences·Thomas Ho-Yin Lee, Suk-Yu Yau

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Methods Mentioned

BETA
nuclear translocation
blood draws
ELISA
electrophoresis
blood

Key Resources (RRID) Mentioned

AB_325427
AB_10649040
AB_2536381
AB_2714189

Software Mentioned

Any
ImageJ

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