Sex differences in immunohistochemical expression and capillary density in pancreatic solid pseudopapillary neoplasm

Annals of Diagnostic Pathology
Kenichi HirabayashiNaoya Nakamura

Abstract

Solid pseudopapillary neoplasm (SPN) is a rare and low-grade malignant pancreatic neoplasm. Solid pseudopapillary neoplasm is rare in men, and most SPN cases are in young women. This study aimed to investigate sex differences in SPN clinical histopathology including capillary density and expression of immunochemical markers, including glypican 3. A total of 22 resected tumors from pancreatic SPN patients, including 16 women (73%) and 6 men (27%), were analyzed histopathologically and immunohistochemically for synaptophysin, β-catenin, estrogen receptor, progesterone receptor, Ki-67, CD10, CD31, and glypican 3. The median age was 52.5 years in men and 24 years in women (P = .046). The median tumor size was 22.5 mm in men and 40 mm in women (P = .337). In 11 of the 16 women (69%), but in none of the men, tumors showed complete or incomplete fibrous cap`sules (P = .006). Cholesterol clefts were observed in tumors from 10 women (63%) but in none from the men (P = .012). No significant sex differences were noted in tumor characteristics, including size, macroscopic cystic degeneration, necrosis, lymphovascular involvement, and perineural invasion. The SPNs were weakly positive for glypican 3, although there was no significant differ...Continue Reading

References

Apr 15, 2005·Nature·Tannishtha Reya, Hans Clevers
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Mar 9, 2006·Virchows Archiv : an International Journal of Pathology·Yu TakahashiSetsuo Hirohashi
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Mar 13, 2009·Organogenesis·Yuko Komiya, Raymond Habas
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Jun 8, 2013·World Journal of Gastroenterology : WJG·Kenichi HirabayashiNaoya Nakamura
Apr 1, 2011·Clinical Journal of Gastroenterology·Kana TajimaTetsuya Mine

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Citations

Aug 30, 2017·Medical Molecular Morphology·Masahiko TanigawaHirohisa Yano
Jun 19, 2019·Pathology Oncology Research : POR·Attila Zalatnai, Viktória Kis-Orha
Jul 25, 2019·Medicine·Simona GurzuIoan Jung
Dec 2, 2020·Journal of Experimental & Clinical Cancer Research : CR·Lidong CaoRanji Cui
Mar 20, 2018·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Peng WangYi Miao

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