Sex differences in intracellular Ca(2+) accumulation following eccentric contractions of rat skeletal muscle in vivo

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Takashi SonobeYutaka Kano

Abstract

It is commonly believed that estrogen and sex influences play significant effects in skeletal muscle damage following eccentric exercise. The mechanistic bases for this sex-specific phenomenon remain to be resolved. The muscle damage has been linked to loss of Ca(2+) homeostasis and resultant intramyocyte Ca(2+) ([Ca(2+)](i)) accumulation; therefore, we tested the hypothesis that the greater eccentric exercise-induced muscle damage in males would be associated with more pronounced [Ca(2+)](i) accumulation. The intact spinotrapezius muscle of adult Wistar rats [male, female, and ovariectomized (OVX)-to investigate the effects of estrogen] was exteriorized. Tetanic eccentric contractions (100 Hz, 700-ms duration, 20 contractions/min for a total of 10 sets of 50 contractions) were elicited by electrical stimulation during synchronized muscle stretch of 10% resting muscle length. The fluorescence ratio (F(340)/F(380) nm) was determined from images captured following each set of contractions, and fura-2 AM was used to estimate [Ca(2+)](i) and changes thereof. Following eccentric contractions, [Ca(2+)](i) increased significantly in male (42.8 ± 5.3%, P < 0.01) but not in female (9.4 ± 3.5%) rats. OVX evidenced an intermediate respons...Continue Reading

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Citations

May 30, 2013·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·José MagalhãesAntónio Ascensão
Sep 17, 2014·Cell Calcium·Hiroaki EshimaYutaka Kano
Apr 26, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hiroaki EshimaYutaka Kano
Jul 26, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hiroaki EshimaYutaka Kano
Jan 10, 2020·Journal of Applied Physiology·Daiki WatanabeYutaka Kano
May 8, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hiroaki EshimaYutaka Kano
Oct 31, 2019·BioMed Research International·J HadreviK Søgaard
Nov 19, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ryo TakagiYutaka Kano

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