Sex differences in language dysfunction in schizophrenia

The American Journal of Psychiatry
Deborah J WalderJ M Goldstein

Abstract

Normal sex differences in language functions are disrupted in schizophrenia. However, identification of specific language components most vulnerable in schizophrenia and how they may differ by sex remain unexamined. The current study investigated this issue in the domains of phonology, semantics, and grammar, which have been closely linked with neuroanatomic regions for which sex differences have been identified. Thirty-one outpatients with DSM-III-R schizophrenia and 27 healthy subjects comparable within sex on age, handedness, parental socioeconomic status, and ethnicity were systematically ascertained from a Boston catchment area. The subjects were administered an extensive language battery in the context of a comprehensive neuropsychological battery that included measures of phonology, semantics, and grammar. Male patients performed significantly worse than their healthy counterparts on all three domains, with phonology least affected. In contrast, language function was relatively preserved in the female patients, compared to their healthy counterparts, with phonology most affected. Across domains, the effect sizes in comparisons of male patients and healthy male subjects had a twofold difference, whereas the difference in ...Continue Reading

Citations

May 24, 2011·Reviews in Endocrine & Metabolic Disorders·Julie A Markham
Jun 27, 2008·The Behavioral and Brain Sciences·Bernard Crespi, Christopher Badcock
Jul 9, 2010·Developmental Neuropsychology·Chiara SpironelliAlessandro Angrilli
Jun 27, 2008·Schizophrenia Bulletin·Ann M Kring, Erin K Moran
Oct 15, 2013·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Timothy J Crow
Nov 15, 2006·Brain Research·William Davies, Lawrence S Wilkinson
Jun 5, 2007·Biological Psychiatry·Kelly P CosgroveJulie K Staley
Feb 19, 2008·Schizophrenia Research·D J WalderE F Walker
Jan 4, 2015·European Psychiatry : the Journal of the Association of European Psychiatrists·S IttigA Riecher-Rössler
Jul 13, 2016·Schizophrenia Research·Fay Y WomerDeanna M Barch
Jun 24, 2017·Nature Reviews. Neuroscience·Margaret M McCarthyKathryn M Lenz
Jan 26, 2011·The Australian and New Zealand Journal of Psychiatry·Wing Chung ChangEric Y H Chen
Jun 30, 2016·World Journal of Psychiatry·Mary V Seeman
Nov 4, 2020·European Psychiatry : the Journal of the Association of European Psychiatrists·Martina VanovaVeena Kumari

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.