Sex differences in large conducting airway anatomy

Journal of Applied Physiology
Paolo B DominelliMichael J Joyner

Abstract

Airway luminal area is the major determinant of resistance to airflow in the tracheobronchial tree. Women may have smaller central conducting airways than men; however, previous evidence is confounded by an indirect assessment of airway geometry and by subjects with prior smoking history. The purpose of this study was to examine the effect of sex on airway size in healthy nonsmokers. Using low-dose high-resolution computed tomography, we retrospectively assessed airway luminal area in healthy men ( n = 51) and women ( n = 73) of varying ages (19-86 yr). Subjects with a positive smoking history, cardiopulmonary disease, or a body mass index > 40 kg/m2 were excluded. Luminal areas of the trachea, right and left main bronchus, bronchus intermediate, left and right upper lobes, and the left lower lobe were analyzed at three discrete points. The luminal areas of the conducting airways were ~26%-35% smaller in women. The trachea had the largest differences in luminal area between men and women (298 ± 47 vs. 195 ± 28 mm2 or 35% smaller for men and women, respectively), whereas the left lower lobe had the smallest differences (57 ± 15 vs. 42 ± 9 mm2 or 26% smaller for men and women, respectively). When a subset of subjects was matched ...Continue Reading

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Citations

Apr 2, 2019·American Journal of Physical Anthropology·Daniel García-MartínezYann Heuzé
Mar 1, 2019·Exercise and Sport Sciences Reviews·Paolo B DominelliA William Sheel
Feb 1, 2020·Experimental Physiology·Juan G RipollPaolo B Dominelli
Apr 17, 2020·Journal of Applied Physiology·Dragoş M VasilescuJames C Hogg
Dec 6, 2018·European Journal of Applied Physiology·Devin B PhillipsStewart R Petersen
Dec 10, 2019·European Journal of Applied Physiology·Paige A ReinhardBruno Archiza
Jul 24, 2020·Journal of Applied Physiology·Leah M MannPaolo B Dominelli
Mar 15, 2021·Mayo Clinic Proceedings·Paolo B DominelliMichael J Joyner
Apr 28, 2021·European Journal of Applied Physiology·Bruno ArchizaA William Sheel
May 28, 2021·Journal of Biomechanical Engineering·Meryll Grace B CastroWilliam F Pritchard
Aug 1, 2021·European Journal of Applied Physiology·Leah M MannPaolo B Dominelli
Oct 29, 2021·Journal of Applied Physiology·Carli M PetersAndrew William Sheel
Nov 12, 2021·The Clinical Respiratory Journal·Kohei ShikanoKoichiro Tatsumi
Dec 23, 2021·Journal of Speech, Language, and Hearing Research : JSLHR·James C Borders, Michelle S Troche
Jan 14, 2022·European Respiratory Review : an Official Journal of the European Respiratory Society·Paolo B Dominelli, Yannick Molgat-Seon

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