Sex differences in limbic network and risk-taking propensity in healthy individuals.

Journal of Neuroscience Research
Sahil Bajaj, William D S Killgore

Abstract

Little is known about the structural neural substrates that may contribute to sex differences in risk-taking propensity (RTP). A close association between risk-seeking behavior and the emotional-regulation network led us to hypothesize that the sex differences in RTP would be associated with sex differences in brain morphometry of the limbic network (LN). We collected RTP scores using the bubble sheet version of the evaluation of risk (EVAR) scale and neuroanatomical data from 57 healthy individuals (29 males). The EVAR scale included sub-scales measuring recklessness/impulsivity, self-confidence, and need for control (NFC). We observed significant sex differences in NFC showing greater desire for control and dominance in males than females (multivariate analysis of covariance, MANCOVAN: p = .01). Morphometry analysis showed that it was only the right LN, which showed significant sex differences in normalized surface area, normalized cortical volume, and adjusted mean curvature index (females > males) at p < .01 (MANCOVAN, corrected for multiple comparisons). Correlation analysis showed that greater curvature of the right LN was significantly associated with lower desire for control in high-risk events (r = -.31, p = .02 at 95%...Continue Reading

References

Sep 14, 2000·Proceedings of the National Academy of Sciences of the United States of America·B Fischl, A M Dale
Aug 17, 2002·Cerebral Cortex·Ruben C GurRaquel E Gur
Dec 11, 2002·IEEE Transactions on Medical Imaging·Ph G BatchelorA F Dean
Dec 5, 2003·Cerebral Cortex·Bruce FischlAnders M Dale
Jan 16, 2007·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Daniel D DresslerAlpesh N Amin
Oct 9, 2007·Cerebral Cortex·Gabriele LohmannAlan C F Colchester
Jan 9, 2008·Journal of Personality and Social Psychology·David P SchmittJüri Allik
Feb 1, 2008·Cerebral Cortex·Kiho ImSun I Kim
Mar 14, 2009·Neurobiology of Aging·Débora TerribilliGeraldo F Busatto
Apr 1, 2007·Indian Journal of Psychiatry·V Rajmohan, E Mohandas
Aug 18, 2010·Psychological Reports·William D S KillgoreThomas J Balkin
May 27, 2011·Nature Neuroscience·Margaret M McCarthy, Arthur P Arnold
Jun 10, 2011·Journal of Neurophysiology·B T Thomas YeoRandy L Buckner
Jun 23, 2011·PLoS Biology·Simon Baron-CohenRebecca Knickmeyer
Oct 28, 2011·Nature·Hyo Jung KangNenad Sestan
Aug 23, 2012·Biology of Sex Differences·Jay N GieddRhoshel K Lenroot
Jun 12, 2013·Clinical Science·Rodrigo Maranon, Jane F Reckelhoff
Jul 16, 2013·Neuroscience and Biobehavioral Reviews·Marco CataniMichel Thiebaut de Schotten
Jan 1, 2014·Neuroscience and Biobehavioral Reviews·Amber N V RuigrokJohn Suckling
Jan 21, 2014·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Edmund T Rolls
May 7, 2014·Psychiatry Research·Samuel J DeWittFrancesca M Filbey
Mar 19, 2016·Lancet Neurology·Carolyn M Mazure, Joel Swendsen
Nov 22, 2016·Journal of Neuroscience Research·Aarthi R GobinathLiisa A M Galea
Feb 9, 2017·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Anne B ArnettRichard K Olson
Jan 13, 2018·Frontiers in Aging Neuroscience·Sahil BajajWilliam D S Killgore
May 18, 2018·Cerebral Cortex·Stuart J RitchieIan J Deary

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.