Sex Differences in Long-Term Mortality and Functional Outcome After Rehabilitation in Patients With Severe Stroke

Frontiers in Neurology
Domenico ScrutinioRosanna Tortelli

Abstract

Objective: We sought to determine sex differences in outcomes in patients with severe stroke who had been admitted to inpatient rehabilitation. Methods: We studied 1,316 patients aged 18 to 99 (mean 72) classified as case-mix groups 0108, 0109, and 0110 of the Medicare case-mix classification system. These groups encompass the most severe strokes. Three outcomes were analyzed: (1) 3-year mortality from admission to rehabilitation; (2) combined outcome of transfer to acute care or death within 90 days from admission to rehabilitation; (3) functional outcome, including proportional recovery in motor functioning and good functional outcome as defined by achievement of a Functional Independence Measure (FIM)-motor score ≥65 points at discharge. Multivariable regression analyses were used to assess sex-difference in each outcome between women and men. The covariates examined included age, marital status, comorbidities, time from stroke onset to rehabilitation admission <30 days, ischemic stroke, dysphagia, neglect, motor FIM score at admission, and cognitive FIM score at admission. Results: Kaplan-Meier estimated 3-year mortality rate was 20.7% in women and 22.0% in men. The crude hazard ratio (HR) of death for women compared with m...Continue Reading

References

Sep 8, 2001·Stroke; a Journal of Cerebral Circulation·H Brønnum-HansenUNKNOWN Danish MONICA Study Group
Jul 3, 2007·Archives of Physical Medicine and Rehabilitation·Kim A BrockSusan M Cotton
Jan 31, 2008·BMJ : British Medical Journal·Karsten Bruins SlotUNKNOWN Lothian Stroke Register
Aug 30, 2008·Lancet Neurology·Mathew J ReevesLynda Lisabeth
Jun 16, 2009·Epidemiology·Enrique F SchistermanRobert W Platt
Jun 10, 2010·The New England Journal of Medicine·K Kian AngMaura L Gillison
Feb 9, 2011·Circulation·Gustavo SaposnikUNKNOWN Stroke Outcomes Research Canada (SORCan) Working Group
Mar 21, 2013·JAMA : the Journal of the American Medical Association·Loes C A Rutten-JacobsFrank-Erik de Leeuw
Sep 27, 2013·BMJ Open·Gerald Choon-Huat KohAmardeep Thind
Jan 31, 2015·Stroke; a Journal of Cerebral Circulation·Lynda D LisabethLewis B Morgenstern
Feb 26, 2015·Stroke; a Journal of Cerebral Circulation·Allen W BrownCarl V Granger
Jul 8, 2015·Journal of the American Heart Association·Christian DehlendorffTom Skyhøj Olsen
Sep 5, 2015·Stroke; a Journal of Cerebral Circulation·Domenico ScrutinioPietro Fiore
Jan 23, 2016·Journal of the American College of Cardiology·Roxanne PelletierUNKNOWN GENESIS-PRAXY Investigators
Jun 16, 2016·Cell Metabolism·Steven N Austad, Kathleen E Fischer
Apr 24, 2017·Archives of Physical Medicine and Rehabilitation·Chien-Min ChenPau-Chung Chen
Sep 19, 2017·Lancet Neurology·Cathy M Stinear
Oct 24, 2017·Neurosciences : the Official Journal of the Pan Arab Union of Neurological Sciences·Danah K AboAlSamhAli M Al-Khathaami
Nov 8, 2017·Archives of Physical Medicine and Rehabilitation·Cheng-Yang HsiehSheng-Feng Sung
Nov 25, 2017·Journal of Thrombosis and Haemostasis : JTH·P CorrainiH T Sørensen
Dec 20, 2017·Atherosclerosis·I-Kuan WangUNKNOWN Taiwan Stroke Registry Investigators
Feb 14, 2018·Stroke; a Journal of Cerebral Circulation·Seana GallLynda D Lisabeth
Feb 14, 2018·European Heart Journal·Justin B Echouffo-TcheuguiGregg C Fonarow
May 24, 2018·Seminars in Neurology·Mira Katan, Andreas Luft
Jul 30, 2018·Archives of Physical Medicine and Rehabilitation·Domenico ScrutinioSimona Spaccavento
Feb 17, 2019·Neurology·Marios K GeorgakisMartin Dichgans
Feb 24, 2019·Neurology·Martin SöderholmUNKNOWN International Stroke Genetics Consortium, the NINDS-SiGN Consortium, and the Genetics of Ischaemic Stroke Functional Outcome
Mar 23, 2019·Journal of Women's Health·Hoang T PhanDominique A Cadilhac
May 21, 2019·Stroke; a Journal of Cerebral Circulation·Opeolu AdeoyeEdward C Jauch
Jun 5, 2019·European Journal of Epidemiology·Denis Talbot, Victoria Kubuta Massamba
Nov 7, 2019·Nature·Cara TannenbaumLonda Schiebinger

❮ Previous
Next ❯

Citations

Nov 3, 2020·Current Neurology and Neuroscience Reports·Corinne A JonesMing-Chieh Ding
Nov 20, 2020·Scientific Reports·Domenico ScrutinioGiovanni D'Addio
May 27, 2021·Journal of Thrombosis and Thrombolysis·Gregory PiazzaSamuel Z Goldhaber

❮ Previous
Next ❯

Methods Mentioned

BETA
coronary artery bypass

Software Mentioned

STATA

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.