Sex differences in nicotine-induced impulsivity and its reversal with bupropion in rats.

Journal of Psychopharmacology
Javier Íbias, Arbi Nazarian

Abstract

Enhancement in cognitive impulsivity and the resulting alterations in decision making serve as a contributing factor for the development and maintenance of substance-use disorders. Nicotine-induced increases in impulsivity has been previously reported in male humans and rodents. Although the potential for sex differences in nicotine-induced impulsivity has not been examined. In the present study, male and female Sprague Dawley rats were submitted to a delay discounting task, in which several consecutive measures of self-control were taken. Firstly, rats were tested with vehicle, and next with nicotine doses of 0.4 and 0.8 mg/kg. Thereafter, chronic treatment with bupropion started, and the animals were tested again. Half the animals continued to receive 0.8 mg/kg of nicotine, while the rest received nicotine and also a daily dose of 30 mg/kg of bupropion. When the animals were first tested with nicotine, female rats showed a significant nicotine dose dependent increase of impulsive behaviour, whereas male rats only showed a decrease on their elections of the larger but delayed reward under the highest dose of 0.8 mg/kg of nicotine. Treatment with bupropion blocked the effect of nicotine on decision making in female rats, as the...Continue Reading

References

Jan 1, 1990·Journal of Personality and Social Psychology·S J Dickman
Dec 1, 1988·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·C G Nwosu, P A Crooks
Jan 1, 1982·Pharmacology & Therapeutics·J S Hendry, J A Rosecrans
May 1, 1995·Journal of the American Academy of Child and Adolescent Psychiatry·L L BarrickmanE Schumacher
Jan 1, 1995·Medicinal Research Reviews·I P StolermanM Shoaib
Jan 1, 1996·British Medical Bulletin·R PetoR Doll
Oct 23, 1997·The New England Journal of Medicine·R D HurtP M Sullivan
Jun 9, 1998·Annals of the New York Academy of Sciences·D Brunner, R Hen
Sep 2, 1998·Psychopharmacology·N R Mirza, I P Stolerman
Mar 4, 1999·The New England Journal of Medicine·D E JorenbyT B Baker
Nov 7, 1999·Psychopharmacology·J L Evenden
Nov 7, 1999·Psychopharmacology·S H Mitchell
Feb 9, 2000·Psychopharmacology·S ShiffmanJ DeVeaugh-Geiss
Nov 10, 2000·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·K A PerkinsA R Caggiula
Jul 17, 2001·Journal of Clinical Pharmacology·J J StewartJ E Manno
Nov 3, 2001·The American Journal of Psychiatry·F G MoellerA C Swann
May 15, 2003·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Stevens S SmithTimothy B Baker
Nov 19, 2003·European Journal of Pharmacology·Huibert D MansvelderArjen B Brussaard
May 18, 2004·Nature Neuroscience·Margaret E Rice, Stephanie J Cragg
May 21, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Catharine A WinstanleyTrevor W Robbins
Jul 1, 2004·Drug and Alcohol Dependence·Stephanie T LanzaRobert L Balster
Feb 12, 2005·Behavioural Pharmacology·J Dallery, M L Locey
Mar 1, 2006·Clinical Psychology Review·Catharine A WinstanleyTrevor W Robbins
Nov 15, 2006·Drug and Alcohol Dependence·Warren K BickelJeffery A Pitcock
Jul 20, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Emma S J RobinsonTrevor W Robbins
Aug 24, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Rachel NavarraMark Day
Oct 24, 2007·Behavioural Brain Research·Andrew T FoxMark P Reilly
May 21, 2008·Experimental and Clinical Psychopharmacology·Ashley Acheson, Harriet de Wit
Jul 5, 2008·Psychopharmacology·Jennifer L Perry, Marilyn E Carroll
Jan 6, 2009·Pharmacology, Biochemistry, and Behavior·Laura E O'Dell, Taline V Khroyan
Jun 6, 2009·The International Journal of Biochemistry & Cell Biology·Hugo R Arias

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Citations

Jul 8, 2021·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Rodolfo J FloresIan A Mendez
Aug 25, 2021·Psychopharmacology·Nidia Espinoza SerranoArbi Nazarian

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