Sex differences in opioid reinforcement under a fentanyl vs. food choice procedure in rats

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
E Andrew TownsendMatthew L Banks

Abstract

Clinical evidence suggest that men are more sensitive than women to the abuse-related effects of mu-opioid agonists. In contrast, preclinical studies suggest the opposite sex difference. The aim of the present study was to clarify this discrepancy using a fentanyl vs. diluted Ensure® choice procedure to assess sex differences in opioid reinforcement. Sex differences in intravenous (IV) fentanyl self-administration were examined under a fixed-ratio (FR5) schedule, a multi-day progressive-ratio (PR) schedule for behavioral economic analysis, and a concurrent (choice) schedule of fentanyl and diluted Ensure® reinforcement in Sprague-Dawley male and female rats. The fentanyl dose-effect function under the FR5 schedule was significantly shifted upward in females compared to males. Similarly, the reinforcing effectiveness of both fentanyl (3.2 and 10 µg/kg per injection, IV) and diluted Ensure® (18 and 56%) were greater in females than in males as assessed using behavioral economic analysis, irrespective of dose or concentration. However, under a fentanyl vs. foodchoice procedure, males chose 3.2 µg/kg per injection fentanyl injections over 18%, but not 56%, diluted Ensure® at a higher percentage compared to females. Overall, these r...Continue Reading

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Citations

May 2, 2020·Journal of Neurochemistry·Suzanne O NolanErin S Calipari
Jan 30, 2020·Psychopharmacology·Tommy GunawanDavid N Kearns
May 7, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Munir Gunes KutluErin S Calipari
Jun 6, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Cody A Siciliano
Aug 26, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S Stevens Negus, Matthew L Banks
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Feb 2, 2021·Neuropharmacology·Arbi NazarianThomas J Martin
Apr 10, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Samantha O BrownCharles W Bradberry
Apr 9, 2021·Peptides·Richard J Bodnar
Apr 26, 2021·Psychopharmacology·Samantha G MaloneMichael T Bardo
Apr 27, 2021·Current Protocols·Anna K RadkeSean C Monroe
May 21, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Eden M AndersonMatthew C Hearing

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