Sex differences in physical dependence on orally self-administered phencyclidine (PCP) in rhesus monkeys (Macaca mulatta)

Experimental and Clinical Psychopharmacology
Jennifer L PerryMarilyn E Carroll

Abstract

Withdrawal from orally self-administered phencyclidine (PCP) has been shown to alter operant baselines of food-maintained responding. The goal of the present study was to determine whether there are sex differences in these alterations. Seven female and 7 male rhesus monkeys (Macaca mulatta) were given concurrent access to PCP and water under fixed ratio (FR) 8 schedules during 2 daily sessions that alternated with 2 sessions during which pellet deliveries were contingent on lever presses under an FR 64 schedule. After operant responding stabilized, PCP was replaced by water for 10 days, and food access remained under the same schedule. Subsequently, concurrent PCP and water access was reintroduced for 10 days. This procedure was repeated with 3 PCP concentrations (0.125, 0.25, and 0.50 mg/ml) and 3 FR requirements for food-reinforced responding (64, 128, and 256). Disruptions in operant responding for food served as a quantitative measure of withdrawal severity. During PCP withdrawal, males showed a greater suppression of food-maintained behavior than females at the 2 highest PCP concentrations and the lowest FR requirement tested. Males responded more than females for PCP; however, when weight was taken into consideration, PC...Continue Reading

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Citations

Feb 24, 2016·Frontiers in Psychiatry·Marilyn E Carroll, John R Smethells
Jan 17, 2016·Pharmacological Reviews·Jill B Becker, George F Koob
Jan 2, 2016·Pharmacological Reviews·Styliani GoulopoulouR Clinton Webb
Jan 13, 2009·Drug and Alcohol Dependence·Marilyn E CarrollJennifer L Perry
Mar 31, 2007·Journal of Perianesthesia Nursing : Official Journal of the American Society of PeriAnesthesia Nurses·Meg Voelker, Terri G Foster
May 15, 2007·Pharmacology, Biochemistry, and Behavior·Jennifer L PerryMarilyn E Carroll
Aug 12, 2008·Behavioural Pharmacology·Marilyn E CarrollNancy K Dess
Oct 13, 2009·Hormones and Behavior·Marilyn E Carroll, Justin J Anker

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