Sex differences in presenting symptoms of acute coronary syndrome: the EPIHeart cohort study

BMJ Open
Carla AraújoAna Azevedo

Abstract

Prompt diagnosis of acute coronary syndrome (ACS) remains a challenge, with presenting symptoms affecting the diagnosis algorithm and, consequently, management and outcomes. This study aimed to identify sex differences in presenting symptoms of ACS. Data were collected within a prospective cohort study (EPIHeart). Patients with confirmed diagnosis of type 1 (primary spontaneous) ACS who were consecutively admitted to the Cardiology Department of two tertiary hospitals in Portugal between August 2013 and December 2014. Presenting symptoms of 873 patients (227 women) were obtained through a face-to-face interview. Typical pain was defined according to the definition of cardiology societies. Clusters of symptoms other than pain were identified by latent class analysis. Logistic regression was used to quantify differences in presentation of ACS symptoms by sex. Chest pain was reported by 82% of patients, with no differences in frequency or location between sexes. Women were more likely to feel pain with an intensity higher than 8/10 and this association was stronger for patients aged under 65 years (interaction P=0.028). Referred pain was also more likely in women, particularly pain referred to typical and atypical locations simult...Continue Reading

References

Apr 1, 1999·Annual Review of Physiology·R D Foreman
Apr 20, 2000·The New England Journal of Medicine·J H PopeH P Selker
Jun 24, 2000·JAMA : the Journal of the American Medical Association·J G CantoC I Kiefe
Jul 18, 2002·Heart & Lung : the Journal of Critical Care·Holli A DeVon, Julie Johnson Zerwic
Mar 27, 2003·Nursing Research·Holli A DeVon, Julie Johnson Zerwic
Mar 5, 2004·The American Journal of Cardiology·Kerry A MilnerRobert J Goldberg
Jul 21, 2004·Journal of the National Cancer Institute. Monographs·Christine MiaskowskiKathryn Lee
Nov 24, 2005·JAMA : the Journal of the American Medical Association·Clifford J Swap, John T Nagurney
Oct 24, 2006·The American Journal of Cardiology·Cynthia Arslanian-EngorenKim A Eagle
Mar 16, 2007·Nursing Research·Catherine J RyanJulie J Zerwic
Dec 20, 2007·Nursing Research·Teri G LindgrenYvonne L Munn
Mar 1, 2008·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Rudi BruyninckxFrank Buntinx
Mar 10, 2010·American Heart Journal·Barbara RiegelKathleen Dracup
Jun 22, 2010·Heart & Lung : the Journal of Critical Care·Cynthia Arslanian-Engoren, Milo Engoren
Feb 24, 2012·JAMA : the Journal of the American Medical Association·John G CantoUNKNOWN NRMI Investigators
Aug 28, 2012·European Heart Journal·Kristian ThygesenUNKNOWN ESC Committee for Practice Guidelines (CPG)
Sep 18, 2013·JAMA Internal Medicine·Nadia A KhanUNKNOWN GENESIS PRAXY Team
Nov 28, 2013·JAMA Internal Medicine·Maria Rubini GimenezChristian Mueller
Apr 4, 2014·Journal of the American Heart Association·Holli A DevonMohamud Daya
Apr 20, 2014·BMC Emergency Medicine·Alexander KamaliUlf Ekelund
Aug 21, 2014·European Heart Journal·Melanie NicholsMike Rayner
Nov 22, 2014·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Basmah SafdarDeborah B Diercks
Apr 2, 2016·European Journal of Cardiovascular Nursing : Journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology·Holli A DeVonLani Zimmerman
Jul 7, 2016·International Journal of Cardiology·Olivia ManfriniUNKNOWN ISACS-TC Investigators
Aug 31, 2016·European Heart Journal. Acute Cardiovascular Care·Francois SchieleHector Bueno

❮ Previous
Next ❯

Citations

Nov 13, 2019·European Heart Journal·Puja K MehtaC Noel Bairey Merz
Mar 2, 2019·BMJ Open·Ralf E HarskampHenk C P M van Weert
Mar 27, 2020·Journal of the American Heart Association·Holli A DeVonJessica Zègre-Hemsey
Sep 22, 2018·BioResearch Open Access·Holli A DeVonJessica Zegre-Hemsey
Oct 11, 2020·Current Cardiology Reports·Lindsey TrutterMartha Gulati
Feb 11, 2019·Journal of Emergency Nursing : JEN : Official Publication of the Emergency Department Nurses Association·Sahereh MirzaeiHolli A DeVon

❮ Previous
Next ❯

Methods Mentioned

BETA
coronary artery bypass

Software Mentioned

R
CRUSADE
GRACE
STATA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.