Sex differences in psychiatric comorbidity and plasma biomarkers for cocaine addiction in abstinent cocaine-addicted subjects in outpatient settings

Frontiers in Psychiatry
María PedrazFrancisco Javier Pavón

Abstract

There are sex differences in the progression of drug addiction, relapse, and response to therapies. Because biological factors participate in these differences, they should be considered when using biomarkers for addiction. In the current study, we evaluated the sex differences in psychiatric comorbidity and the concentrations of plasma mediators that have been reported to be affected by cocaine. Fifty-five abstinent cocaine-addicted subjects diagnosed with lifetime cocaine use disorders (40 men and 15 women) and 73 healthy controls (48 men and 25 women) were clinically assessed with the diagnostic interview "Psychiatric Research Interview for Substance and Mental Disorders." Plasma concentrations of chemokines, cytokines, N-acyl-ethanolamines, and 2-acyl-glycerols were analyzed according to history of cocaine addiction and sex, controlling for covariates age and body mass index (BMI). Relationships between these concentrations and variables related to cocaine addiction were also analyzed in addicted subjects. The results showed that the concentrations of chemokine (C-C motif) ligand 2/monocyte chemotactic protein-1 (CCL2/MCP-1) and chemokine (C-X-C motif) ligand 12/stromal cell-derived factor-1 (CXCL12/SDF-1) were only affecte...Continue Reading

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Citations

Dec 15, 2017·Addictive Disorders & Their Treatment·Adriana FarréMarta Torrens
Sep 5, 2018·The European Journal of Neuroscience·Rebecca S HoffordDrew D Kiraly
Apr 24, 2019·Journal of Psychopharmacology·Susana Barbosa Méndez, Alberto Salazar-Juárez
Jun 22, 2019·PloS One·Breno Sanvicente-VieiraRodrigo Grassi-Oliveira
May 28, 2019·Reviews in the Neurosciences·Bárbara Dos Anjos RosárioMilena de Barros Viana
Jun 28, 2016·AIDS Research and Human Retroviruses·Meena SunilTanvir K Bell
Feb 6, 2017·Frontiers in Psychiatry·Nuria García-MarchenaFrancisco Javier Pavón
Jun 21, 2018·Frontiers in Genetics·Carolina Torres-Rojas, Byron C Jones
Mar 2, 2018·Frontiers in Psychiatry·Nuria García-MarchenaFernando Rodríguez de Fonseca
Feb 26, 2021·Drug and Alcohol Dependence·April C MayUNKNOWN T1000 Investigators

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Methods Mentioned

BETA
ELISA

Software Mentioned

GraphPad Prism
Bio
GraphPad
CIDI
SPSS Statistical
Plex Manager
PRISM

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