Sex Differences in Reported Adverse Drug Reactions of Selective Serotonin Reuptake Inhibitors

Drug Safety : an International Journal of Medical Toxicology and Drug Experience
Corine EkhartEugène P van Puijenbroek

Abstract

Several studies have investigated sex as a risk factor for the occurrence of adverse drug reactions (ADRs) and found that women are more likely to experience ADRs than men. The aim of this explorative study was to investigate whether differences exist in reported ADRs of selective serotonin reuptake inhibitors (SSRIs) for men and women in the database of the Netherlands Pharmacovigilance Centre Lareb. A ratio of reports concerning women and men, corrected for the number of users, was calculated for all the ADRs reported on SSRIs. We found that 16 ADRs were statistically significantly more reported in women than men, and four ADRS were reported more in men than women. ADRs more reported in women than men when using SSRIs were usually dose-related ADRs or commonly occurring ADRs. Differences in the pharmacokinetics of SSRIs between men and women may explain why these reports of dose-related ADRs when using SSRIs concern women more than men.

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Citations

Jan 31, 2019·Acta Psychiatrica Scandinavica·A BraillonF Naudet
Dec 18, 2019·Pharmacology Research & Perspectives·Ann M MoyerVirginia M Miller
Feb 6, 2020·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Andrew J WebbJeffrey E Topal
Jan 14, 2021·Pharmacy : Journal of Pharmacy, Education and Practice·Homero Contreras-SalinasLourdes Yolotzin Rodríguez-Herrera
Jul 20, 2021·Advanced Drug Delivery Reviews·José das NevesBruno Sarmento
Jul 29, 2021·Nature Reviews. Endocrinology·Michelle M Mielke, Virginia M Miller

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