Sex Differences in Risk for Alzheimer's Disease Related to Neurotrophin Gene Polymorphisms: The Cache County Memory Study

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Joshua MatyiMona Buhusi

Abstract

Neurotrophins, including nerve-growth factor and brain-derived neurotrophic factor, have been implicated in Alzheimer's disease (AD). Associations between AD and neurotrophin signaling genes have been inconsistent, with few studies examining sex differences in risk. We examined four single-nucleotide polymorphisms (SNPs) involved in neurotrophin signaling (rs6265, rs56164415, rs2289656, rs2072446) and risk for AD by sex in a population-based sample of older adults. Three thousand four hundred and ninety-nine individuals without dementia at baseline [mean (standard deviation) age = 74.64 (6.84), 58% female] underwent dementia screening and assessment over four triennial waves. Cox regression was used to examine time to AD or right censoring for each SNP. Female carriers of the minor T allele for rs2072446 and rs56164415 had a 60% (hazard ratio [HR] = 1.60, 95% confidence interval [CI] = 1.02-2.51) and 93% (HR = 1.93, 95% CI = 1.30-2.84) higher hazard for AD, respectively, than male noncarriers of the T allele. Furthermore, male carriers of the T allele of rs2072446 had a 61% lower hazard (HR = 0.39, 95% CI = 0.14-1.06) than male noncarriers at trend-level significance (p = .07). The association between certain neurotrophin gene ...Continue Reading

References

Mar 1, 1987·American Journal of Physical Anthropology·L B Jorde, K Morgan
May 17, 2000·Journal of Clinical Epidemiology·A S KhachaturianJ C Breitner
Feb 13, 2001·American Journal of Epidemiology·L E HebertD A Evans
Aug 25, 2001·Annual Review of Neuroscience·E J Huang, L F Reichardt
Jun 6, 2003·Neuropathology and Applied Neurobiology·D Dawbarn, S J Allen
Nov 15, 2003·Journal of Clinical Epidemiology·Kathleen M HaydenUNKNOWN Cache County Study Group
Jan 29, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jieli ChenMichael Chopp
May 18, 2005·Neuroscience Letters·Diane OlinDavid E Comings
Dec 20, 2005·Journal of Neural Transmission·C LaskeK Schott
Apr 22, 2006·Journal of Alzheimer's Disease : JAD·Jenny Y-J ChuuGreer M Murphy
Sep 11, 2008·Journal of Alzheimer's Disease : JAD·Arianna CozzaSilvia Pellegrini
Nov 7, 2008·Expert Review of Neurotherapeutics·Elliott J MufsonStephen D Ginsberg
Aug 15, 2009·Journal of Molecular Neuroscience : MN·A Claudio CuelloM Florencia Iulita
Sep 11, 2009·Annals of Neurology·Julie A SchneiderDavid A Bennett
Sep 24, 2010·The International Journal of Neuropsychopharmacology·Christoph LaskeThomas Leyhe
Nov 4, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Nela PivacDorotea Muck Seler
Jan 22, 2011·Psychiatry Investigation·Bun-Hee Lee, Yong-Ku Kim
Feb 5, 2011·Nature Protocols·Geraldine M ClarkeKrina T Zondervan
Feb 9, 2011·Archives of General Psychiatry·Aristotle N VoineskosJames L Kennedy
Sep 8, 2011·Neuromolecular Medicine·Breno Satler Diniz, Antonio Lucio Teixeira
Sep 9, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Latha Devi, Masuo Ohno
Sep 29, 2011·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Tomoyuki NagataHisashi Yamada
Jun 2, 2012·Current Neuropharmacology·Shelley J AllenDavid Dawbarn
Sep 4, 2012·Molecular Neurobiology·Antonino Cattaneo, Pietro Calissano
Feb 6, 2013·Neuroscience·N PluchinoA R Genazzani
Feb 27, 2013·Psychiatry and Clinical Neurosciences·Yuichiro WatanabeToshiyuki Someya
May 22, 2013·Neuropharmacology·Pedro BekinschteinJorge H Medina
Aug 21, 2013·Biological Psychiatry·Mark T W EbbertJohn S K Kauwe
Sep 12, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Zhentao ZhangKeqiang Ye
Jan 29, 2014·Clinical Epidemiology·Michelle M MielkeWalter A Rocca
Feb 13, 2014·Brain : a Journal of Neurology·M Florencia IulitaA Claudio Cuello
Aug 1, 2014·BMC Bioinformatics·Aaron R SharpUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Mar 19, 2015·Cognitive, Affective & Behavioral Neuroscience·Ana KimUNKNOWN Alzheimer’s Disease Neuroimaging Initiative

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Citations

Sep 11, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Chelsea L SandersJoann T Tschanz
Aug 30, 2020·Disease Models & Mechanisms·Julia GamacheOrnit Chiba-Falek
Aug 16, 2018·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Samira S ValvassoriJoão Quevedo
Jul 18, 2019·Frontiers in Neuroscience·Elliott J MufsonMilos D Ikonomovic
Apr 13, 2021·Cellular and Molecular Life Sciences : CMLS·Donghui ZhuZhen Zhao

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