Sex differences in shotgun proteome analyses for chronic oral intake of cadmium in mice

PloS One
Yoshiharu YamanobeToshihiro Takizawa

Abstract

Environmental diseases related to cadmium exposure primarily develop owing to industrial wastewater pollution and/or contaminated food. In regions with high cadmium exposure in Japan, cadmium accumulation occurs primarily in the kidneys of individuals who are exposed to the metal. In contrast, in the itai-itai disease outbreak that occurred in the Jinzu River basin in Toyama Prefecture in Japan, cadmium primarily accumulated in the liver. On the other hand, high concentration of cadmium caused renal tubular disorder and osteomalacia (multiple bone fracture), probably resulting from the renal tubular dysfunction and additional pathology. In this study, we aimed to establish a mouse model of chronic cadmium intake. We administered cadmium-containing drinking water (32 mg/l) to female and male mice ad libitum for 11 weeks. Metal analysis using inductively coupled plasma mass spectrometry revealed that cadmium accumulated in the kidneys (927 x 10 + 185 ng/g in females and 661 x 10 + 101 ng/g in males), liver (397 x 10 + 199 ng/g in females and 238 x 10 + 652 ng/g in males), and thyroid gland (293 + 93.7 ng/g in females and 129 + 72.7 ng/g in males) of mice. Female mice showed higher cadmium accumulation in the kidney, liver, and th...Continue Reading

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Citations

Jun 9, 2016·International Journal of Molecular Sciences·Jana DumkovaMarcela Buchtova
Oct 13, 2019·Scientific Reports·Jamie L YoungJonathan H Freedman
Feb 27, 2018·The Journal of Toxicological Sciences·Sailendra Nath SarmaMasahiko Satoh
Apr 24, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jia-Qiao ZhuZong-Ping Liu
Apr 14, 2018·Journal of Proteomics·Xuefang LiangChristopher J Martyniuk
Apr 3, 2021·Epigenetics : Official Journal of the DNA Methylation Society·Max T AungM Daniele Fallin
May 14, 2021·Ecotoxicology and Environmental Safety·Jiaqiao ZhuZongping Liu

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Methods Mentioned

BETA
light microscopy
chemical modification
electron microscopy

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Mascot Generic
Excel
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StatPlus

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