Sex differences in sleep: impact of biological sex and sex steroids

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Jessica A Mong, Danielle M Cusmano

Abstract

Men and women sleep differently. While much is known about the mechanisms that drive sleep, the reason for these sex differences in sleep behaviour is unknown and understudied. Historically, women and female animals are underrepresented in studies of sleep and its disorders. Nevertheless, there is a growing recognition of sex disparities in sleep and rhythm disorders. Women typically report poorer quality and more disrupted sleep across various stages of life. Findings from clinical and basic research studies strongly implicate a role for sex steroids in sleep modulation. Understanding how neuroendocrine mediators and sex differences influence sleep is central to advancing our understanding of sleep-related disorders. The investigation into sex differences and sex steroid modulation of sleep is in its infancy. Identifying the mechanisms underlying sex and gender differences in sleep will provide valuable insights leading to tailored therapeutics that benefit each sex. The goal of this review is to discuss our current understanding of how biological sex and sex steroids influence sleep behaviour from both the clinical and pre-clinical perspective.

References

Jul 1, 1988·Chest·C GuilleminaultG Nino-Murcia
Aug 1, 1986·Journal of Applied Physiology·B K SchneiderD P White
Jun 1, 1971·Physiology & Behavior·M BrancheyR D Nadler
Jan 1, 1984·Neuroscience and Biobehavioral Reviews·S S Campbell, I Tobler
Jan 1, 1983·Neuropsychobiology·H Kleinlogel
Mar 3, 1983·The New England Journal of Medicine·R E SandblomD J Pierson
Mar 1, 1994·American Journal of Respiratory and Critical Care Medicine·S RedlineV Ferrette
May 1, 1996·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·H A MiddelkoopC P Springer
Feb 1, 1996·The Journal of Clinical Endocrinology and Metabolism·H S DriverA A Borbély
Oct 10, 1997·American Journal of Obstetrics and Gynecology·C J ChuongI Karacan
Nov 14, 1997·Journal of Sleep Research·C L Ehlers, D J Kupfer
Nov 7, 1998·Brain Research·B SchwierinI Tobler
Nov 20, 1998·Maturitas·J F Owens, K A Matthews
Mar 23, 2000·Progress in Neurobiology·J C HendricksA I Pack
Apr 18, 2000·Sleep Medicine·S L CamhiS F Quan
Mar 10, 2001·The Journal of Clinical Endocrinology and Metabolism·R LuboshitzkyP Lavie
Jul 4, 2001·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·M Méndez, R A Radtke
Aug 21, 2001·Pflügers Archiv : European journal of physiology·F C BakerH S Driver
Mar 16, 2002·Journal of Applied Physiology·Fiona C BakerDuncan Mitchell
Aug 17, 2002·Chronobiology International·Ana Adan, Vincenzo Natale
Dec 5, 2002·Journal of Sleep Research·Jacqueline VockClaudio L Bassetti
Jan 18, 2003·Sleep Medicine Reviews·Roseanne Armitage, Robert F. Hoffmann
Jan 28, 2003·Archives of Internal Medicine·Najib T AyasFrank B Hu
May 17, 2003·Sleep·Muriel KoehlFred W Turek
Aug 14, 2003·The Journal of Clinical Endocrinology and Metabolism·Peter Y LiuDavid J Handelsman
Nov 1, 1957·Electroencephalography and Clinical Neurophysiology·W DEMENT, N KLEITMAN
Feb 21, 2004·Journal of the American College of Cardiology·Hans K Meier-EwertJanet M Mullington
Feb 26, 2004·Archives of Internal Medicine·Susan RedlineAnne Newman
Apr 17, 2004·The Medical Clinics of North America·Margaret L MolineRochelle Zak

❮ Previous
Next ❯

Citations

Feb 3, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Margaret M McCarthy
Nov 9, 2017·International Journal of Environmental Research and Public Health·Nicola Magnavita, Sergio Garbarino
Oct 19, 2017·Pediatric Exercise Science·María Reyes Beltran-VallsDiego Moliner-Urdiales
Nov 29, 2017·Current Obesity Reports·Jamie E CobornJennifer A Teske
Apr 25, 2018·The Journal of Physiology·Laura BennetRosemary S C Horne
Feb 13, 2018·Journal of Genetic Counseling·Krister W FjermestadLise B Hoxmark
Jan 18, 2018·Journal of Child Neurology·Réjean M GuerrieroWilliam P Meehan
Dec 7, 2018·Journal of Aging and Physical Activity·Charity B BrenemanXuewen Wang
Apr 20, 2017·Internal Medicine Journal·Amanuel A AbajobirJake M Najman
Oct 19, 2019·Journal of Sleep Research·Eliana S ButlerRobert-Paul Juster
Dec 1, 2019·Sleep·Kevin M SwiftGina R Poe
Jan 29, 2020·Journal of Sleep Research·Andréia Gomes BezerraHelena Hachul
Feb 26, 2020·Journal of Women's Health·Chandra L JacksonAlberto Ramos
Jan 14, 2020·Molecular Neurobiology·Kirsten GustTuong-Vi Nguyen
Sep 12, 2019·Journal of Abnormal Child Psychology·Sunhye BaiTara S Peris
Jun 23, 2020·Advances in Physiology Education·Rehana Khan LeakDiane C Rhodes
Jul 4, 2020·Journal of Sleep Research·Gabriel Natan PiresMonica Levy Andersen
May 29, 2020·The Journal of Obstetrics and Gynaecology Research·Kaeko SumiyoshiTsuyomu Ikenoue
Sep 13, 2019·Aging & Mental Health·Elliottnell PerezMichael Marsiske
Aug 1, 2020·Endocrinology·Alana M C Brown, Nicole J Gervais
Aug 10, 2017·Metabolic Brain Disease·Ewa Drozdowicz-JastrzębskaMaria Radziwoń-Zaleska
Feb 10, 2019·International Journal of Environmental Research and Public Health·Melissa D OlfertSarah E Colby
Oct 18, 2019·Frontiers in Neuroscience·Radoslawa Herzog-Krzywoszanska, Lukasz Krzywoszanski
May 30, 2020·Journal of Sleep Research·Børge SivertsenLaila Arnesdatter Hopstock
Jun 23, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Angelina M M SantosoUNKNOWN NET-QUBIC consortium
Mar 1, 2019·Sleep & Breathing = Schlaf & Atmung·Aitor MartinezAguirre-BetolazaIñigo Mujika
Jan 20, 2020·Calcified Tissue International·Gregorio BevilacquaElaine M Dennison
Jun 14, 2018·BMC Public Health·Claire E KimDaehee Kang
Aug 25, 2020·Current Treatment Options in Neurology·Eric M DavisMark Quigg
May 7, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Galen MissigWilliam A Carlezon
Oct 28, 2019·BMC Public Health·Adriana N MudryjAndrea E Bombak
Feb 8, 2019·Current Psychiatry Reports·Michael R DolsenAric A Prather
Mar 19, 2020·Canadian Journal of Public Health = Revue Canadienne De Santé Publique·Sohrab Amiri, Sepideh Behnezhad

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Jessica A MongRae Silver
Journal of Vascular Surgery
Jean E Starr, Vivienne Halpern
© 2021 Meta ULC. All rights reserved