Sex differences in the 1 H NMR metabolic profile of serum in cardiovascular risk patients

Scientific Reports
Ignasi BarbaDavid Garcia-Dorado

Abstract

Personalized diagnosis and risk stratification of cardiovascular diseases would allow optimizing therapeutic strategies and lifestyle changes. Metabolomics is a promising technique for personalized diagnosis and prognosis; however, various physiological parameters, including sex, influence the metabolic profile thus hampering its translation to the clinic. Knowledge of the variation in the metabolic profile associated with sex would facilitate metabolomic translation to the clinic. The objective of the present work was to investigate the possible differences in the metabolic 1H NMR profile associated to sex beyond lipoproteins. 1H NMR spectra from whole serum and methanol deproteinized samples from 39 patients (22 males, 17 females) between 55-70 years old with suspected coronary artery disease that underwent a stress test that was considered negative where included. Deproteinized serum could be used to differentiate sex based on higher levels of lactate and glucose in women. Lipoprotein region was the most variable area of the spectra between individuals, but spectra of whole serum were able to differentiate sex based on lipoproteins. There are sex-related differences in the 1H NMR metabolic profile of individuals with suspect...Continue Reading

References

Apr 21, 2006·Nature·T Andrew ClaytonJeremy K Nicholson
May 30, 2006·Nature Medicine·Heide L KirschenlohrJames C Metcalfe
Nov 21, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Mika Ala-Korpela
Jun 27, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ignasi BarbaDavid Garcia-Dorado
Apr 10, 2009·JACC. Cardiovascular Imaging·Linda R PetersonRobert J Gropler
Apr 29, 2009·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Anders Nordström, Rolf Lewensohn
Mar 2, 2011·PloS One·Nikolaos PsychogiosDavid S Wishart
Aug 20, 2011·PLoS Genetics·Kirstin MittelstrassThomas Illig
Nov 30, 2011·Clinical Chemistry·Lauren G Gilstrap, Thomas J Wang
Feb 14, 2013·Pflügers Archiv : European journal of physiology·Carin WittnichMichael Belanger
May 7, 2014·Analytical Chemistry·G A Nagana Gowda, Daniel Raftery
Oct 20, 2015·Journal of Magnetic Resonance·G A Nagana Gowda, Daniel Raftery
Mar 26, 2016·Circulation Research·Heinrich TaegtmeyerUNKNOWN American Heart Association Council on Basic Cardiovascular Sciences
Jul 5, 2016·Biological & Pharmaceutical Bulletin·Kosuke SaitoYoshiro Saito
Apr 1, 2017·Circulation. Cardiovascular Genetics·Susan ChengUNKNOWN American Heart Association Council on Functional Genomics and Translational Biology; Council on Cardiovascular and Stroke Nu
Aug 19, 2017·Journal of Atherosclerosis and Thrombosis·Takuro Miyazaki, Akira Miyazaki

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Methods Mentioned

BETA
NMR

Clinical Trials Mentioned

NCT02968771

Software Mentioned

Chenomx
SIMCA

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