Sex differences in the anatomical and functional organization of the periaqueductal gray-rostral ventromedial medullary pathway in the rat: a potential circuit mediating the sexually dimorphic actions of morphine.

The Journal of Comparative Neurology
Dayna R Loyd, Anne Z Murphy

Abstract

Previous studies have demonstrated that morphine, administered systemically or directly into the periaqueductal gray (PAG), produces a significantly greater degree of antinociception in males in comparison with females. Because the midbrain PAG and its descending projections to the rostral ventromedial medulla (RVM) constitute an essential neural circuit for opioid-based analgesia, the present studies were conducted to determine whether sex differences in the anatomical organization of the PAG-RVM pathway, and its activation during persistent inflammatory pain, could account for sex-based differences in opioid analgesia. In the rat, retrograde tracing was combined with Fos immunocytochemistry to investigate sexual dimorphism in the organization of the PAG-RVM circuit and its activation by persistent inflammatory pain induced by intraplantar injection of complete Freund's adjuvant (CFA). The ability of morphine to suppress the activation of the PAG-RVM circuit was also examined. Sexually dimorphic retrograde labeling was observed within the dorsomedial and lateral/ventrolateral PAG at all rostrocaudal levels, with females having significantly more PAG-RVM output neurons in comparison with males. While no sex differences were not...Continue Reading

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Citations

Dec 3, 2008·Behavioral Neuroscience·N DevidzeM J Kreek
Aug 18, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·L Marson, A Z Murphy
Dec 19, 2012·Biology of Sex Differences·Kathleen A SlukaWendy M Kohrt
May 12, 2011·PloS One·Charlotte A CornilThierry D Charlier
Dec 26, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dayna R LoydAnne Z Murphy
Dec 3, 2013·Pharmacology, Biochemistry, and Behavior·J G VeeningP O Gerrits
Nov 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Hui-Bing WuLee-Ming Kow
Apr 16, 2014·Experimental Neurology·Dayna R Loyd, Anne Z Murphy
Dec 24, 2008·Women's Health·Jen Richardson, Anita Holdcroft
Oct 4, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lori N Eidson, Anne Z Murphy
Jan 10, 2016·The Journal of Pain : Official Journal of the American Pain Society·Katherine A MifflinBradley J Kerr
Oct 29, 2013·The Journal of Pain : Official Journal of the American Pain Society·Melissa L MehalickMichael M Morgan
Jul 23, 2013·Frontiers in Neuroendocrinology·Richard J Traub, Yaping Ji
Jul 2, 2015·Basic & Clinical Pharmacology & Toxicology·Anna Kosiorek-Witek, Helena Elżbieta Makulska-Nowak
Nov 14, 2012·The Journal of Pain : Official Journal of the American Pain Society·Jan HendrichJon D Levine
Feb 23, 2011·Frontiers in Neuroendocrinology·Loretta M Flanagan-Cato
Mar 12, 2009·Physiology & Behavior·Anne Z MurphyRichard J Traub
Oct 24, 2007·Peptides·Richard J Bodnar
Mar 27, 2007·The Journal of Pain : Official Journal of the American Pain Society·Yaping JiRichard J Traub
Nov 23, 2006·Behavioural Brain Research·Scott A BernalRebecca M Craft
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Oct 19, 2010·Life Sciences·Khampaseuth Rasakham, Lee-Yuan Liu-Chen
Jun 9, 2015·Frontiers in Behavioral Neuroscience·Emily M Perez-TorresAnnelyn Torres-Reveron
Feb 12, 2013·The Journal of Pain : Official Journal of the American Pain Society·Lori N Eidson, Anne Z Murphy
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