Sex Differences in the Association Between Measures of General and Central Adiposity and the Risk of Myocardial Infarction: Results From the UK Biobank

Journal of the American Heart Association
Sanne A E PetersMark Woodward

Abstract

There are substantial differences in the distribution of adipose tissue between women and men. We assessed the sex-specific relationships and their differences between measures of general and central adiposity and the risk of incident myocardial infarction (MI). Between 2006 and 2010, the UK Biobank recruited over 500 000 participants aged 40 to 69 years across the United Kingdom. During 7 years of follow-up, 5710 cases of MI (28% women) were recorded among 265 988 women and 213 622 men without a history of cardiovascular disease at baseline. Cox regression models yielded adjusted hazard ratios for MI associated with body mass index, waist circumference, waist-to-hip ratio, and waist-to-height ratio. There was an approximate log-linear relationship between measures of general and central adiposity and the risk of MI in both sexes. A 1-SD higher in body mass index, waist circumference, waist-to-hip ratio, and waist-to-height ratio, respectively, were associated with hazard ratios (confidence intervals) for MI of 1.22 (1.17; 1.28), 1.35 (1.28; 1.42), 1.49 (1.39; 1.59), and 1.34 (1.27; 1.40) in women and of 1.28 (1.23; 1.32), 1.28 (1.23; 1.33), 1.36 (1.30; 1.43), and 1.33 (1.28; 1.38) in men. The corresponding women-to-men ratios ...Continue Reading

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Citations

Aug 3, 2019·Journal of Community Health·Jewel ScottLeigh Ann Simmons
Jan 5, 2020·Biology of Sex Differences·Rianneke de RitterSanne A E Peters
Jul 18, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Pengfei ZhuNatalie Staplin
Oct 20, 2020·Frontiers in Neurology·Irene GöttgensSabine Oertelt-Prigione
Mar 18, 2021·Complementary Therapies in Medicine·Karen L SabanLinda Witek Janusek
Apr 23, 2021·Advances in Nutrition·Penny Gordon-LarsenSaame Raza Shaikh

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