PMID: 11335054May 4, 2001Paper

Sex differences in the cerebral blood flow response after brief hypercapnia in the rat

Neuroscience Letters
B M AncesJ A Detre

Abstract

Hypercapnia primarily affects cerebral blood flow (CBF) and not cerebral metabolism. We compared the CBF responses due to electrical forepaw stimulation before and after brief hypercapnia in male, non-ovarectomized female, and ovarectomized female rats. Prior to hypercapnia the CBF responses were similar for all three groups. Seven minutes after brief hypercapnic exposure the CBF responses to forepaw stimulation were augmented in all groups. However, both 30 and 60 min after hypercapnia, the magnitude of the CBF responses to forepaw stimulation remained elevated for males and ovarectomized females, but not for non-ovarectomized females. These results suggest that estrogen may modulate the upregulation of the CBF response observed after transient hypercapnia.

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Nov 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·B SchmitzK A Hossmann
Sep 9, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·E Hösli, L Hösli

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Citations

Jan 3, 2012·Climacteric : the Journal of the International Menopause Society·C T DebertM J Poulin
Apr 21, 2017·ACS Chemical Neuroscience·Lindsay R WaltonR Mark Wightman
Aug 12, 2017·Experimental Physiology·Jill N Barnes
Nov 3, 2007·Menopause : the Journal of the North American Menopause Society·Emese SzelkeSzabolcs Varbiro
Jun 24, 2006·Journal of Applied Physiology·Diana N KrauseDale A Pelligrino
Mar 19, 2009·Pharmacological Reviews·Noboru TodaTomio Okamura
Nov 6, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jill N Barnes, Nisha Charkoudian

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