Sex differences in the distribution of axon types within the genu of the rat corpus callosum

Brain Research
C M MackV H Denenberg

Abstract

Neuroanatomical sex differences have been documented in the rat neocortex, including dimorphism of its predominant commissure, the corpus callosum (CC). In particular, CC sex differences have been reported in the ultrastructure of the posterior callosal region, the splenium. Since the CC is a heterogeneous fiber tract with its axons arising from distinct cortical areas and passing through restricted regions along its length, it became of interest to ascertain whether cellular sexual dimorphisms may also be present in another division of the CC. To test this hypothesis, electron microscopy was used to examine axon composition in adult male and female rats in the anterior portion, the genu. The number and size of axons, the thickness of the myelin sheath, and the area within the genu occupied by these constituents, were quantified. Results showed a significant sex difference in the ratio of unmyelinated to myelinated axons, with females having a larger proportion of unmyelinated fibers. This effect was present for both (1) the number of axons, and (2) the area taken up by axonal fibers. No differences were found in the size of either axon type, or for myelin thickness. Comparison of these results with those from the splenium and ...Continue Reading

Citations

Jun 26, 2003·Anatomia, histologia, embryologia·M F SargonM Cumhur
Jul 7, 2007·The International Journal of Neuroscience·Mustafa F SargonM Mustafa Aldur
Dec 17, 2008·Journal of Neuroscience Research·Muthulekha SwamydasRobert Skoff
Jul 28, 2019·Anatomia, histologia, embryologia·Duaa Al QattanMaha ELBeltagy
Apr 25, 2007·The International Journal of Neuroscience·Mustafa F SargonErgün Karaağaoğlu
Jun 25, 2020·International Journal of Molecular Sciences·Li LiXu Cui
May 9, 2013·Hormones and Behavior·Takefumi KikusuiKazutaka Mogi
Jan 12, 2021·Cerebral Cortex·Zhijie LiaoTomas Paus

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