Sex differences in the effect of acute administration of nicotine on MRS-measured metabolic profile of the rat brain.

Neuroscience Research
Serguei Liachenko, Jaivijay Ramu

Abstract

Women are less able to stop smoking than men. Elucidation of sex differences in the tobacco addiction could facilitate personalized treatment. Specialized brain reward systems are controlling the behavior through reinforcement using specific neuromediators. Using non-invasive magnetic resonance spectroscopy (MRS) to ascertain addiction/harm biomarkers could lead to better management of public health through advancements in regulatory and translational research. Proton MRS was used to monitor changes of specific neurometabolites in hippocampus (HC), nucleus accumbens (NAC), and anterior cingulate cortex (ACC) of rats of both sexes after single intraperitoneal injection of nicotine. At the baseline, male rats showed higher level of GABA, taurine, N-acetyl aspartate, and creatine in HC, and taurine in NAC. Also, there were stronger correlations between neurometabolites in females than in males at the baseline. Nicotine administration changed taurine, GABA, myo-inositol, choline, and N-acetyl aspartate in HC, and taurine in NAC. Significant interactions between time, treatment, and sex were detected for taurine and choline in HC. The number of inter-metabolite correlations increased significantly in ACC and decreased in NAC and HC ...Continue Reading

References

Jan 1, 1993·Developmental Neuroscience·A BrandD Leibfritz
Jun 19, 2001·NMR in Biomedicine·S W Provencher
Jul 31, 2001·CNS Drugs·K A Perkins
Oct 6, 2001·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·S Pogun
May 15, 2003·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Michele D LevineKenneth A Perkins
May 4, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Martin KanowskiClaus Tempelmann
Oct 29, 2005·The Journal of Comparative Neurology·Roy A Wise
Dec 31, 2005·Metabolic Brain Disease·Jan Albrecht, Michał Wegrzynowicz
Feb 6, 2007·Progress in Neurobiology·John R MoffettAryan M A Namboodiri
Aug 5, 2008·Neuropharmacology·William A Carlezon, Mark J Thomas
Jun 30, 2009·Seminars in Cell & Developmental Biology·Huibert D MansvelderLorna W Role
Jul 11, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ivan TkácRolf Gruetter
Dec 17, 2009·Drug and Alcohol Dependence·Justin J Anker, Marilyn E Carroll
Mar 6, 2010·Annals of the New York Academy of Sciences·Stephanie C Licata, Perry F Renshaw
Sep 14, 2010·The International Journal of Biochemistry & Cell Biology·Marcelo O Ortells, Hugo R Arias
Oct 12, 2010·International Archives of Medicine·Oscar Arias-CarriónErnst Pöppel
Apr 22, 2011·Advances in Psychosomatic Medicine·Eliot L Gardner
May 28, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yasmin MashhoonMarc J Kaufman
Sep 14, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Linda ChangThomas M Ernst
Mar 22, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yan LinPeter G Morris
Apr 10, 2012·PloS One·Lars MichelsRuth L O'Gorman
Aug 1, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Dinesh Kumar DeelchandPierre-Gilles Henry
Feb 15, 2014·Addictive Behaviors·Reagan R WetherillTeresa R Franklin
Feb 27, 2014·Radiology·Gülin OzUNKNOWN MRS Consensus Group
Jun 24, 2014·Radiology·Frederik BarkhofSerge A R B Rombouts
Jan 8, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Petr BednaříkSilvia Mangia
Aug 19, 2015·Journal of the American Psychiatric Nurses Association·Tracy HellemPerry F Renshaw
Dec 15, 2015·Magnetic Resonance Imaging·Ricardo C G LandimGabriela Castellano
Oct 1, 1998·Addiction Biology·N L Benowitz, D Hatsukami

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Jun 25, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Natalie M ZahrAdolf Pfefferbaum

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