Sex differences in the effect of chronic mild stress on mouse prefrontal cortical BDNF levels: A role of major ovarian hormones

Neuroscience
Bhanu Chandra KarisettySumana Chakravarty

Abstract

Depression induced by stress is affected by sex, age and hormonal status of the animal and also by duration and type of the stressors. Moreover, higher prevalence of depression and comorbidities in women than men implies the need to include the sex variable in studies on animal models of depression. The present study was therefore initiated to evaluate the effect of sex and ovarian hormones on depression-like phenotypes in mice exposed to a 21-day Chronic Variable Mild Stress (CVMS) paradigm. Adult male, intact female and, ovariectomized (OVX) female mice exposed to CVMS displayed despair behavior, a depression-like phenotype, in all the groups. However, intact females alone, but not males and OVX females, showed anhedonia, another depression-like phenotype. At the molecular level, the expression of Brain-Derived Neurotrophic Factor (BDNF), a neuropeptide associated with depression, and few other stress-specific genes CRH, NR3C1, CART, and NPY were measured in the Prefrontal Cortex (PFC) region of the reward circuitry. There was a significant decrease in the BDNF protein expression along with an increase in the mRNA expression of CRH, NR3C1, CART, and NPY in intact females, but not in the other two groups of mice. OVX females r...Continue Reading

Citations

Sep 16, 2018·Journal of Molecular Neuroscience : MN·Karem H AlzoubiFeras Q Alali
Oct 2, 2019·Current Neuropharmacology·Kaipuzha Venu AthiraSumana Chakravarty
Aug 8, 2020·The Journal of Pharmacology and Experimental Therapeutics·Gustavo A Martinez-Muniz, Susan K Wood
Nov 13, 2018·Frontiers in Cellular Neuroscience·Elisa MarcheseMaria Concetta Geloso
Aug 28, 2018·AIMS Neuroscience·Pranav Chintamani Joshi, Sugato Benerjee
Jul 19, 2019·Biology of Sex Differences·Sierra J StringfieldDonita L Robinson
Feb 23, 2020·International Journal of Molecular Sciences·Zhuang MiaoZhongsheng Sun
Jun 12, 2020·Frontiers in Behavioral Neuroscience·Arish Mudra Rakshasa, Michelle T Tong
Jun 28, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jill B Becker, Elena Chartoff
Feb 2, 2021·Frontiers in Psychiatry·Thomas Jan KonturekMiriam Goebel-Stengel
Feb 8, 2021·Behavioural Brain Research·Ying XueMengqi Zhang
Nov 17, 2020·Frontiers in Behavioral Neuroscience·Dakota F Brockway, Nicole A Crowley
Feb 26, 2021·Neural Plasticity·Xianquan AnYang Jin
Mar 9, 2021·Pharmacology, Biochemistry, and Behavior·Bommana Raghunath ReddySumana Chakravarty
Apr 16, 2019·Journal of Psychiatric Research·Toshiyuki MizuiMasami Kojima
Nov 28, 2018·Neuroscience and Biobehavioral Reviews·Elizabeth T Barfield, Shannon L Gourley
Mar 3, 2018·The Journal of Pain : Official Journal of the American Pain Society·Yaping JiRichard J Traub

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