PMID: 9185158Jul 1, 1997Paper

Sex differences in the effects of gonadectomy and acute swim stress on GABAA receptor binding in mouse forebrain membranes

Neurochemistry International
M K Akinci, G A Johnston

Abstract

Gonadectomy of male mice resulted in a significant increase in GABAA receptor binding in forebrain membranes at GABA concentrations of 100-1000 nM, whereas gonadectomy of female mice resulted in no significant change in such binding. Acute swim stress (3 min swim at 32 degrees C) in gonadectomised female mice resulted in a significant increase in GABAA receptor binding in forebrain membranes at GABA concentrations of 400-1000 nM and in the plasma levels of corticosterone, whereas this stress produced no significant change in such binding or steroid levels in gonadectomised male mice. The surgical stress of sham gonadectomy produced significant increases in GABAA receptor binding in forebrain membranes at GABA concentrations of 100-1000 nM in both sexes, such that the acute swim stress induced increase in GABAA receptor binding in unoperated females is not observed. Hormone replacement studies in swim stressed gonadectomised females indicate that intraperitoneal injection of oestrogen (beta-oestradiol, 10 micrograms) or progesterone (6 alpha-methyl-17 alpha-hydroxy-progesterone acetate, 1 mg) significantly decreased GABAA receptor binding in forebrain membranes at GABA concentrations of 100-1000 nM compared to swim stressed, gon...Continue Reading

References

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Dec 1, 1993·Physiology & Behavior·B Zimmerberg, M J Farley
Jun 1, 1993·Journal of Neurochemistry·M K Akinci, G A Johnston

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Citations

Dec 20, 2005·Psychopharmacology·Anna-Carin N-WihlbäckTorbjörn Bäckström
Mar 3, 2005·Pharmacology, Biochemistry, and Behavior·Alfredo Briones-ArandaOfir Picazo
Apr 8, 2003·Life Sciences·Rebecca M Craft
Sep 6, 2000·Pharmacology, Biochemistry, and Behavior·D PericićK Mirković
Apr 23, 1999·Neurochemistry International·A D MitrovicG A Johnston
Sep 11, 2004·Psychoneuroendocrinology·Anna-Carin WihlbäckInger Sundström-Poromaa
Jun 9, 2006·Pharmacology, Biochemistry, and Behavior·Jodi E Gresack, Karyn M Frick
Jul 8, 2005·Brain Research. Molecular Brain Research·Rebecca C PiersonL John Greenfield
Oct 23, 2015·International Journal of Endocrinology·Donatas StakisaitisAngelija Valanciute
Dec 17, 2009·Journal of Neurochemistry·Kelly J SkilbeckTina Hinton
Dec 1, 2017·Scientific Reports·Rose JoachimLester Kobzik
Feb 26, 2008·Neurochemistry International·K J SkilbeckG A R Johnston

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