Sex differences in the effects of social and physical environment on novelty-induced exploratory behavior and cocaine-stimulated locomotor activity in adolescent rats.

Behavioural Brain Research
E ZakharovaS Izenwasser

Abstract

Many factors influence the rewarding effects of drugs such as cocaine. The present study was done to determine whether social and environmental factors alter behavior in adolescent male and female rats. On postnatal day (PND) 23, rats were housed in one of several same-sex conditions. Both social (number of rats per cage) and environmental (availability of toys) factors were manipulated. Socially isolated rats were housed alone (1 rat/cage) in an environment that either was impoverished (with no toys; II) or enriched (with toys; IE). Standard housing for these studies was social and impoverished, which was 2 rats/cage with no toys (SI2). Other rats were housed 2/cage with toys (SE2), or 3/cage with (SE3) or without (SI3) toys. On PND 37, novelty-induced locomotor activity was measured for 30min. On PND 44-46, locomotor activity in response to an injection of 5mg/kg cocaine was measured for 60min each day. For male rats, only social conditions altered novelty-induced activity. Males housed in groups of three had the most activity, compared to pair-housed and isolated rats. For females, social and environmental enrichment interacted to alter novelty-induced activity. In contrast to males, isolated females had increased activity, ...Continue Reading

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Citations

Aug 8, 2013·International Journal of Molecular Sciences·Peter KissDora Reglodi
Dec 18, 2014·Alcoholism, Clinical and Experimental Research·Sara Palm, Ingrid Nylander
Dec 3, 2014·Neuroscience and Biobehavioral Reviews·Elizabeth J CroftonThomas A Green
Jul 19, 2013·Behavioural Brain Research·Catrinel Girbovan, Hélène Plamondon
Jul 17, 2019·Journal of Personality·Tim KaiserTom Booth

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