Sex Differences in the Embryonic Development of the Central Oxytocin System in Mice

Journal of Neuroendocrinology
S TamborskiHeather K Caldwell

Abstract

Recent studies suggest that oxytocin (OXT) may be important for organising the neural circuitry that underlies adult social behaviour. Although most of the work exploring these effects has focused on early postnatal development, there is evidence that OXT may also be important during foetal development. However, without an understanding of how the OXT system develops, the ability to functionally link OXT in foetal life to adult behaviour is limited. To understand where and when OXT could be acting during embryonic development to affect the organisation of neural substrates, we examined the development of the mouse OXT system from embryonic day (E) 12.5 through postnatal day (PND) 2 using OXT receptor (OXTR) binding and a quantitative polymerase chain reaction. In both males and females, OXTR binding was observed by E16.5 in the ventricular and subventricular zones, as well as the developing amygdala. In males, OXT mRNA was not detectable until PND2, whereas it was detectable by E16.5 in females. OXTR mRNA was detected by E12.5 in both sexes, although females appear to have more OXTR mRNA during foetal development than males. The present study is significant because it is the first to reveal an unexpected sex difference in the d...Continue Reading

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Citations

Jun 9, 2016·Developmental Neurobiology·Radhika Vaidyanathan, Elizabeth A D Hammock
Aug 12, 2016·Developmental Neurobiology·Heather K CaldwellShannah K Witchey
May 12, 2017·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Heather K Caldwell
Feb 26, 2019·Journal of Neuroscience Research·Angela R FreemanHeather K Caldwell
Dec 18, 2019·Journal of Neuroendocrinology·Radhika Vaidyanathan, Elizabeth A D Hammock
Jan 22, 2020·Journal of Neuroendocrinology·Elizabeth A Aulino, Heather K Caldwell
Jul 31, 2018·Neural Plasticity·Jan BakosZuzana Bacova
Feb 2, 2021·Frontiers in Behavioral Neuroscience·Julietta A ShengRobert J Handa
Apr 28, 2021·Scientific Reports·Masatoshi NaganoHidenori Suzuki
May 16, 2021·Communications Biology·María Pilar Madrigal, Sandra Jurado
May 28, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Livia H MoraisJohn F Cryan
Oct 30, 2021·Journal of Neuroendocrinology·Tatsushi Onaka, Yuki Takayanagi

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